Karyopharm Therapeutics Inc (KPTI) — Titan Protect Analysis

KPTI

Karyopharm Therapeutics Inc

Healthcare · ·

$9.08

Data: 2026-06-03

✓ ETHICAL PASS

NONE MOAT

LIMITED

Data Confidence: 0.0%

Key Metrics

How this company measures up on the fundamentals that matter

Market Cap

$196M

Total market value of the company

Trailing P/E

N/A

Forward P/E

-1.76

Based on estimated future earnings — lower means cheaper

Rev Growth

+16.8%

Year-over-year revenue change

Profit Margin

-129.0%

How much profit the company keeps from each dollar of revenue

ROE

N/A

Return on equity — how efficiently it uses shareholder money

Analyst Target

$14.50

+60% from current price — median analyst estimate

Recommendation

BUY

Consensus view from 6 analysts covering this stock

About Karyopharm Therapeutics Inc

Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases in the United States. The company discovers, develops, and commercializes novel and small molecule Selective Inhibitor of Nuclear Export (SINE) compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead compounds include XPOVIO in combination with bortezomib and dexamethasone for th

https://www.karyopharm.com

Country: United States Employees: 228 Industry: Biotechnology

Ethical Screening

Five compliance checks based on AAOIFI standards — all must pass for ethical clearance

Business Activity

PASS

Core business does not involve prohibited activities

Debt Ratio

0.0% PENDING

Debt must be below 33% of total assets

Cash Ratio

0.0% PENDING

Interest-bearing cash below 33% of assets

Receivables

0.0% PENDING

Receivables below 49% of assets

Revenue Purity

0.0% PENDING

Non-compliant revenue below 5% — any excess requires purification

Quantitative Intelligence

Statistical analysis of price behaviour, risk, and market regime — independent of fundamental data

Regime

MARKDOWN

Price trending down — defensive positioning

Sharpe Ratio

0.178

Positive but modest risk-adjusted returns

Kelly Fraction

0.0041

Marginal edge — very small allocation suggested

Calmar Ratio

-0.282

Drawdown risk outweighs the returns — higher risk profile

Annual Return

-22.1%

Historical annualised return based on price data

Max Drawdown

-78.6%

Largest peak-to-trough decline — the worst it has been

HMM State

BEAR

Statistical model detects bearish conditions

Days in State

How long the current regime has persisted — longer means more stable

Market Data

Trading characteristics and market positioning

Beta

0.81

Less volatile than the market — more defensive

52W High

$10.99

17% below the year high

52W Low

$3.65

149% above the year low

Avg Volume

898,530

Average daily shares traded — higher means easier to buy and sell

Short Ratio

12.7

Days it would take all short sellers to cover — higher means more crowded

Short % Float

N/A

Div Yield

N/A

Annual dividend as a percentage of the share price

EPS (TTM)

$-16.40

Earnings per share over the last 12 months

Financial Health

Balance sheet strength and cash generation — the foundation of long-term value

Debt/Equity

N/A

Current Ratio

N/A

Quick Ratio

N/A

Like current ratio but excludes inventory — stricter test

Gross Margin

13.5%

Revenue left after cost of goods — higher means pricing power

Operating Margin

-76.3%

Profit from core operations before interest and tax

Free Cash Flow

N/A

Negative — the business is spending more than it generates

Revenue (TTM)

$151M

Total revenue over the last 12 months

Net Income

$-194,968,992

Loss-making — spending exceeds revenue after all costs

Analyst Coverage

Analysts

Target High

$16.00

Target Median

$14.50

Target Low

$7.00

Explore the Ethical Screener View Track Record

Data sourced from public filings and market feeds. Not financial advice. Updated: 2026-06-03

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