DNLI
Denali Therapeutics Inc.
Healthcare · Biotechnology · NMS
$20.21
Close 2026-05-28
✗ NOT SCREENED

UNKNOWN MOAT
MODERATE
Data Confidence: 71%
Some financial metrics pending
Market Cap
$3.2B
Trailing P/E
Forward P/E
-8.12
Rev Growth
Profit Margin
0.0%
ROE
-49.6%
Analyst Target
$35.00
Recommendation
STRONG BUY
About Denali Therapeutics Inc.

Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutics to treat neurodegenerative and lysosomal storage diseases. The company develops Eclitasertib (SAR443122/DNL758) RIPK1 inhibitor program for peripheral inflammatory diseases; BIIB122/DNL151 LRRK2 inhibitor program for Parkinson's disease; TAK-594/DNL593 program for frontotemporal dementia-granulin; DNL126 program for MPS IIIA (Sanfilippo Syndrome A); and DNL310 Tividenofusp alfa, an enzyme replacement therapy program for MPS II (Hunter Syndrome). Its Enzyme TransportVehicle (TV) programs include DNL952 for the treatment of Pompe disease; DNL111 for Parkinson's and Gaucher diseases; and DNL622 for Hurler syndrome (MPS I). The company's OTV programs also comprise DNL628 targeting tau for Alzheimer's disease; and DNL422 targeting alpha synuclein for Parkinson's disease, as well as antibody TV program includes DNL921 targeting Abeta for treating Alzheimer's disease. The company was formerly known as SPR Pharma Inc. and changed its name to Denali Therapeutics Inc. in March 2015. Denali Therapeutics Inc. was incorporated in 2013 and is headquartered in South San Francisco, California.

Ethical Screen
Business ActivityPASS
Debt RatioN/A
Cash RatioN/A
Receivables RatioN/A
Revenue RatioN/A
OverallINSUFFICIENT DATA
Score Ethical: 50.0
Score Valuation: 33.0
Score Quality: 21.2
Score Combined: 30.2

Full Analysis

Opportunity scores, earnings history, insider transactions, institutional holders, analyst consensus, and more.

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Opportunity Scores
Valuation50.0
Quality12.5
Cash Flow0.0
Moat40.0
Balance Sheet0.0
Debt Purity50.0
Liquid Purity50.0
Rev Purity50.0
Compliance100.0
Tier: WATCH · Score: 33.5 · Rank: #4878
Insider Transactions
No insider transaction data.
Top Institutional Holders
No institutional holder data.
Additional Fundamentals
Enterprise Value
$2.4B
Price/Book
3.59
Beta
0.995
Analysts
14
Total Debt
$40.0M
Rec. Mean
1.16
Short Ratio
8.23
Short % Float
0.1%
Employees
507

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Trade Consideration
The Opportunity
Score 30.2 (P14 — top 86.3% of scored tickers). Unknown Moat. Ethical FAIL. 15 analysts at Strong Buy.
Price: $20.21 | Target: $33.93 (+68%)
Score
30
Moat
Unknown
Conviction
Standard
Upside
+68%
The Fundamentals
Profit Margin0.0%
ROE-49.6%
Forward P/E-8.1
Market Cap$3.2B
Position Sizing Scenarios
Stop: $17.18 (-15%) | Entry: $20.21
SharesCostProfit to TargetR:R
To Consensus ($33.93, 15 analysts)
10$202.10+$137.20 (68%)4.5R
50$1,010.50+$686.00 (68%)4.5R
100$2,021.00+$1,372.00 (68%)4.5R
Risk Factors
  • Elevated short interest (8.23 days to cover)
The Verdict
Denali Therapeutics Inc. holds a unknown competitive moat.
Quantitative Grade

A single score combining all analytical layers below. A is strongest, D is weakest.

B
Quant Score
68.0
Risk Grade
Layers
7
Risk Profile

How much could this ticker lose on a bad day? These metrics measure worst-case scenarios from historical data.

VaR 95%
-6.4%
worst expected daily loss, 19 in 20 days
CVaR 95%
-8.7%
avg loss on the worst 5% of days
Annual Volatility
Sortino Ratio
0.18
above 1.0 is good
Max Drawdown
-63.7%
Worst Day
Forward Outlook

Based on 10,000 simulated price paths, here is the probability of where this ticker could be in 30, 60, and 90 days.

30d Prob Up
90d Prob Up
Median Return 30d
Liquidity Score
75
Liquidity Grade
LIQUID
Trend & Momentum

What direction is this ticker actually moving, filtered through noise? Is it speeding up or slowing down?

Kalman Trend
Trend Strength
Momentum Signal
HMM Regime
RSI Signal
Technical Signals

Classic chart signals that institutional traders monitor. Golden Cross is bullish, Death Cross is bearish.

MA Crossover
ABOVE_200
Bollinger Position
ABOVE_UPPER
Beta
Relative Volume
1.1x
Short Interest
Financial Health

Is this company financially sound? The Z-Score measures bankruptcy risk. The F-Score measures fundamental strength.

Altman Z-Score
below 1.81 = distress zone
Piotroski F-Score
Earnings Beat Rate
Earnings Consistency
Correlations

These tickers tend to move together (positive) or in opposite directions (negative). Useful for portfolio diversification.

Most Correlated
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Inverse Correlated
TickerCorrelation
SUNC-0.223
BAES.L-0.175
SUKOON.AE-0.159
NMAX-0.143
MO-0.138
Seasonality

Does this ticker have consistent patterns on certain days or months? Historical tendencies, not guarantees.

Best Day
Wednesday
Worst Day
Friday
Best Month
Jan
Worst Month
Feb
Fri-Mon Effect
-0.6085124074903472
Momentum Rankings

How does this ticker's recent performance compare to the entire universe? Ranked across 1, 3, 6, and 12-month returns.

1M Return
+4.4%
3M Return
-2.2%
6M Return
+10.7%
12M Return
+58.6%
Momentum Rank
#1548
Momentum Signal
UP

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