The framework reads distribution. Smart money appears to be selling into strength. Institutional holders may be rotating out. Price has moved down 6.0% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows modest positive risk-adjusted returns. Our composite framework grades it C. Technically it is holding around 39% above its long-term trend line with momentum reading bearish. Over the past year the shares are up 507%. Our forward projection puts the odds of a 10% gain over the next month near 37%. The street (10 analysts) rates it strong buy, with a mean price target of $40.
Alumis Inc.
ALMS · Nasdaq · USD · Market cap $975M · 225 employees
Alumis Inc., a clinical stage biopharmaceutical company, focuses on the development and commercialization of medicines for autoimmune disorders.
FAIL · Does not pass the screenScreen close, 2026-09-21 · not a live quote
Last reviewed 14 days ago
Screened 2026-09-21 · the tape above runs as of 03:09 UTC · two dates, stated on purpose · verdict and workings shown in full · never trimmed
What this means: price 7.90 against the desk's fair-value range, base estimate 39.00, over the last year.
- Trend Markdown
- Insiders no filings inside 60 days, left as found
- Positioning no disclosures inside 60 days, left as found
- Options no verdict drawn today, left as found
- Ethical does not pass the values gate
Our analytic regime reads on this name, dated and marked against the screened price. Small sample per name, and separate from the daily-framework accuracy on the Track Record page.
This name holds its markdown label.
Alumis Inc. holds its Markdown at $7.90. Consolidating, no directional conviction, held for 2 days.
| Phase | Markdown · caution |
| Quantitative state | Consolidating, no directional conviction, held for 2 days |
| Price at the screen | $7.90 |
| Valuation | N/A trailing · -2.92 forward price to earnings |
| Values screen | FAIL · score 70.0 |
| Beta | -0.79 |
Five Screens, Shown in Full
Does not pass. Interest-bearing securities
| Test | Figure | Limit | What it means | Status |
|---|---|---|---|---|
| Business activity | Permissible | Core business clean | Its core business isn't built on prohibited lines: no gambling, alcohol, tobacco, weapons, or interest-based lending. | Pass |
| Debt load | 8.96% | Below 33% | Interest-bearing debt is just 9.0% of its assets, well under the one-third ceiling: it does not run on borrowed money. | Pass |
| Interest-bearing cash | 53.12% | Below 33% | Interest-bearing cash and securities are 53.1% of assets, above the one-third limit. | Fail |
| Receivables | 22.27% | Below 49% | Money owed to the company is 22.3% of assets, under the 49% limit. | Pass |
| Revenue purity | 58.96% | Below 5% | 59.0% of revenue comes from non-compliant sources, over the 5% line. | Fail |
Five checks adapted from AAOIFI screening standards: business activity plus four balance-sheet ratios. All five must pass for ethical clearance. Every figure is arithmetic on public accounts, not judgement.
The Ethical ReadWhy It Falls Short, in Plain English
Alumis's business is fine, but its cash and interest-bearing securities are about 53% of its assets, well over the ~33% line, so it does not pass on the financial screens.
Read as at 2026-10-04. It updates when the underlying figures move, and past reads are kept below.
What the Numbers Say It Is WorthThe Fair Value Range
Fair value range in USD, drawn from the 2026-09-21 screen. The gold marker is the market price at the same screen. A 393.7% margin of safety to the base estimate.
Third-party analyst targets: 8 covering, consensus Strong Buy. The average target sits +305% from the screen price.
Reading the gap · Both our model and the analysts see meaningful upside from here.
Price History & ProjectionsWhere it has been, where the models see it going. History from market close data; projection points are our fair-value estimates and third-party analyst targets, dated to the 2026-09-21 screen.
Fair value and rating are our own model estimates; the Street's range reflects third-party analyst estimates. Analysis, not advice.
The Business, in Plain WordsBiotech Pipeline Hopes Fail Our Basic Test
Picture a lab team staking everything on one TYK2 pill for psoriasis and lupus. That is Alumis today, a clinical-stage name with no approved products and revenue already shrinking fast. We pass despite a fair value gap and a clean ethical screen because the underlying business shows zero profits, deeply negative returns on equity and a forward multiple that simply reflects expected losses.
Analysts see upside to around forty dollars and rate the shares a strong buy, yet those calls rest on future trial data that may or may not arrive. Current metrics paint a firm still burning cash with no moat visible and growth running sharply negative. The valuation gap looks attractive on paper but offers little protection when the next readout disappoints.
Risks sit mainly in binary trial outcomes, dilution and the usual biotech cash burn, all of which explain why the opportunity rating stays at none. Analysis, not advice.
| Forward P/E | -2.9x |
| EPS, trailing | -4.11 |
| EPS, forward | -2.87 |
| Revenue growth | -37.7%revenue is shrinking |
| Profit margin | 0.0%currently unprofitable |
| Return on equity | -93.6%not currently earning a positive return on equity |
| FCF yield | -19.19% |
| Debt to equity | 0.08minimal debt: a conservative balance sheet |
| Current ratio | 6.74comfortably covers its short-term bills |
| Beta | -0.79barely tracks the market's swings |
| Short interest, float | 0.07% |
| 52-week range | 3.76 - 31.35 |
| Market cap | $975M |
| Employees | 225 |
The risks · The things to watch: it's a small-cap, so the share price can swing harder than the market; as a biotechnology name, trial and regulatory outcomes can move it sharply either way.
Plain-English interpretation of our own screen data. Analysis, not advice.
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Every Entry, As Written
The framework has shifted from markdown to distribution since the last review. Smart money appears to be selling into strength. Institutional holders may be rotating out. Price has moved down 69.6% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows modest positive risk-adjusted returns. Our composite framework grades it C. Technically it is holding around 39% above its long-term trend line with momentum reading bearish. Over the past year the shares are up 507%. Our forward projection puts the odds of a 10% gain over the next month near 37%. The street (10 analysts) rates it strong buy, with a mean price target of $40.
The framework reads markdown. Price is trending lower. Sellers are in control and the prior trend has reversed. Price has moved down 3.7% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows good risk-adjusted returns. Our composite framework grades it C. Technically it is holding around 39% above its long-term trend line with momentum reading bearish. Over the past year the shares are up 507%. Our forward projection puts the odds of a 10% gain over the next month near 37%. The street (10 analysts) rates it strong buy, with a mean price target of $40.
The framework reads markdown. Price is trending lower. Sellers are in control and the prior trend has reversed. Price has moved up 18.7% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows good risk-adjusted returns. Our composite framework grades it C. Technically it is holding around 39% above its long-term trend line with momentum reading bearish. Over the past year the shares are up 507%. Our forward projection puts the odds of a 10% gain over the next month near 37%. The street (10 analysts) rates it strong buy, with a mean price target of $40.
The framework reads markdown. Price is trending lower. Sellers are in control and the prior trend has reversed. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows good risk-adjusted returns. Our composite framework grades it C. Technically it is holding around 39% above its long-term trend line with momentum reading bearish. Over the past year the shares are up 507%. Our forward projection puts the odds of a 10% gain over the next month near 37%. The street (10 analysts) rates it strong buy, with a mean price target of $40.
The framework reads markdown. Price is trending lower. Sellers are in control and the prior trend has reversed. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen (70). The risk-adjusted return profile shows good risk-adjusted returns. Our composite framework grades it C. Technically it is holding around 39% above its long-term trend line with momentum reading bearish. Over the past year the shares are up 507%. Our forward projection puts the odds of a 10% gain over the next month near 37%. The street (10 analysts) rates it strong buy, with a mean price target of $40.
The framework reads markdown. Price is trending lower. Sellers are in control and the prior trend has reversed. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen (70). The risk-adjusted return profile shows good risk-adjusted returns.
The framework reads markdown. Price is trending lower. Sellers are in control and the prior trend has reversed. Ethical screening: PASS with passing ethical screen (70). The risk-adjusted return profile shows good risk-adjusted returns.
Each entry above was written on its date, before the outcome. A journal you can prune is not a journal.
- Alumis (ALMS) Plans to Advance Envudeucitinib After LUMUS Missed in the Overall Population Insider Monkey · 26d ago
- Is Alumis (ALMS) Overvalued After Its 121% One Year Return? Simply Wall St. · 3 Sep 2026
- Why Alumis (ALMS) Is Down 56.2% After Mixed Phase 2b Lupus Data Spotlight Biomarker Strategy Simply Wall St. · 3 Sep 2026
- Alumis (ALMS) Looks Pricey After Its Lupus Trial Miss But Is 3x P B Fair? Simply Wall St. · 3 Sep 2026
- Alumis (ALMS) Lead Lupus Drug Missed Phase 2b Trial Endpoints Simply Wall St. · 3 Sep 2026
Headlines from third-party outlets, linked for reference: not our reporting, not advice.
Screened names in the same industry · explore each on its own page.
| Period | Price then | Price return | Divs per share | $1,000 became | Total return |
|---|---|---|---|---|---|
| 1 month | $23.66 | -13.8% | · | $862 | -13.8% |
| 2 months | $23.05 | -11.5% | · | $885 | -11.5% |
| 3 months | $25.03 | -18.5% | · | $815 | -18.5% |
| 6 months | $11.61 | +75.6% | · | $1,756 | +75.6% |
| 1 year | $3.36 | +506.9% | · | $6,069 | +506.9% |
Historical returns from market close data. Past performance does not guarantee future results.
This entry now belongs to the ledger. Whatever ALMS does next, these words stay.
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