The framework has shifted from markup to distribution since the last review. Smart money appears to be selling into strength. Institutional holders may be rotating out. Price has moved up 2.0% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows negative risk-adjusted returns. Our composite framework grades it D, carrying a low risk profile. Technically it is sitting below its long-term trend line with momentum reading bearish. Over the past year the shares are down 39%. Our forward projection puts the odds of a 10% gain over the next month near 25%. The street (19 analysts) rates it strong buy, with a mean price target of $52.
Ultragenyx Pharmaceutical Inc.
RARE · Nasdaq · USD · Market cap $2.6B · 1,371 employees
Ultragenyx Pharmaceutical Inc., a biopharmaceutical company, focuses on the identification, acquisition, development, and commercialization of novel products for the treatment of rare and ultra-rare genetic diseases in N…
FAIL · Does not pass the screenAt the last full screen
2026-08-26
Screened 2026-08-26 · the tape above runs as of 10:31 UTC · two dates, stated on purpose · verdict and workings shown in full · never trimmed
This name holds its distribution label.
Ultragenyx Pharmaceutical Inc. holds its Distribution at $26.44. Consolidating, no directional conviction, held for 71 days.
| Phase | Distribution · caution |
| Quantitative state | Consolidating, no directional conviction, held for 71 days |
| Price at the screen | $26.44 |
| Valuation | N/A trailing · 39.72 forward price to earnings |
| Values screen | FAIL · score 70.0 |
| Beta | 0.31 |
Five Screens, Shown in Full
Does not pass. Business activity: leveraged / inverse / derivative instrument (gharar)
| Test | Figure | Limit | What it means | Status |
|---|---|---|---|---|
| Business activity | Excluded | Core business clean | No prohibited business activity identified | Fail |
| Debt load | 2.35% | Below 33% | Interest-bearing debt is just 2.3% of its assets, well under the one-third ceiling: it does not run on borrowed money. | Pass |
| Interest-bearing cash | 3.72% | Below 33% | Cash held in interest-bearing accounts and securities is 3.7% of assets, under the one-third limit. | Pass |
| Receivables | 37.79% | Below 49% | Money owed to the company is 37.8% of assets, under the 49% limit. | Pass |
| Revenue purity | 3.71% | Below 5% | Only 3.7% of revenue comes from non-compliant sources, under the 5% line. | Pass |
Five checks adapted from AAOIFI screening standards: business activity plus four balance-sheet ratios. All five must pass for ethical clearance. Every figure is arithmetic on public accounts, not judgement.
What the Numbers Say It Is WorthThe Fair Value Range
Fair value range in USD, drawn from the 2026-08-26 screen. The gold marker is the market price at the same screen. A 20.4% margin of safety to the base estimate.
Third-party analyst targets: 19 covering, consensus Strong Buy. The average target sits +85% from the screen price.
Reading the gap · Both our model and the analysts see meaningful upside from here.
Price History & ProjectionsWhere it has been, where the models see it going. History from market close data; projection points are our fair-value estimates and third-party analyst targets, dated to the 2026-08-26 screen.
Fair value and rating are our own model estimates; the Street's range reflects third-party analyst estimates. Analysis, not advice.
The Business, in Plain WordsRare disease biotech offers almost no safety margin
Picture a lab racing to treat conditions so uncommon most doctors will never meet a patient. Ultragenyx fits that brief yet its numbers tell a different story. Revenue is already shrinking and losses remain enormous, so the six percent gap between price and our fair value gives almost no room for the usual setbacks that hit drug developers.
The forward multiple sits at nineteen times earnings while margins sit at minus ninety one percent. That combination leaves little room for execution slips or delays in approvals. Analyst price targets sit far higher, but our reading stays flat because the business shows no durable edge and growth has turned negative.
High cash burn in early stage biotech always carries the risk of dilution or failed trials, and here the thin valuation cushion offers scant protection if either arrives. Ethical screens clear but opportunity does not. Analysis, not advice.
| Forward P/E | 39.7xpriced for continued growth |
| EPS, trailing | -5.83 |
| EPS, forward | 0.67 |
| Revenue growth | +28.1%strong top-line growth |
| Profit margin | -81.7%currently unprofitable |
| FCF yield | -6.90% |
| Current ratio | 1.73healthy short-term liquidity |
| Beta | 0.31barely tracks the market's swings |
| Short interest, float | 0.17% |
| 52-week range | 18.29 - 39.89 |
| Market cap | $2.6B |
| Employees | 1,371 |
The risks · The things to watch: as a biotechnology name, trial and regulatory outcomes can move it sharply either way.
Plain-English interpretation of our own screen data. Analysis, not advice.
Where & How to TradeRARE trades on Nasdaq. As a listed security it is accessible through almost any international broker offering its home market. New to this, or investing from abroad? Our guide to accessing global markets covers brokers, currencies and the practical steps.
Every Entry, As Written
The framework has shifted from markdown to markup since the last review. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Price has moved up 6.4% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows modest positive risk-adjusted returns. Our composite framework grades it D, carrying a low risk profile. Technically it is sitting below its long-term trend line with momentum reading bearish. Over the past year the shares are down 39%. Our forward projection puts the odds of a 10% gain over the next month near 25%. The street (19 analysts) rates it strong buy, with a mean price target of $52.
The framework reads markdown. Price is trending lower. Sellers are in control and the prior trend has reversed. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows negative risk-adjusted returns. Our composite framework grades it D, carrying a low risk profile. Technically it is sitting below its long-term trend line with momentum reading bearish. Over the past year the shares are down 39%. Our forward projection puts the odds of a 10% gain over the next month near 25%. The street (19 analysts) rates it strong buy, with a mean price target of $52.
The framework reads markdown. Price is trending lower. Sellers are in control and the prior trend has reversed. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen (70). The risk-adjusted return profile shows negative risk-adjusted returns.
The framework reads markdown. Price is trending lower. Sellers are in control and the prior trend has reversed. Ethical screening: PASS with passing ethical screen (70). The risk-adjusted return profile shows negative risk-adjusted returns.
Each entry above was written on its date, before the outcome. A journal you can prune is not a journal.
Screened names in the same industry · explore each on its own page.
| Period | Price then | Price return | Divs per share | $1,000 became | Total return |
|---|---|---|---|---|---|
| 1 month | $26.30 | -12.6% | · | $874 | -12.6% |
| 2 months | $23.30 | -1.4% | · | $987 | -1.4% |
| 3 months | $21.71 | +5.9% | · | $1,059 | +5.9% |
| 6 months | $36.20 | -36.5% | · | $635 | -36.5% |
| 1 year | $37.51 | -38.7% | · | $613 | -38.7% |
| 2 years | $41.97 | -45.2% | · | $548 | -45.2% |
| 3 years | $51.38 | -55.3% | · | $447 | -55.3% |
| 5 years | $101.71 | -77.4% | · | $226 | -77.4% |
Historical returns from market close data. Past performance does not guarantee future results.
This entry now belongs to the ledger. Whatever RARE does next, these words stay.
Thirteen thousand names carry this page. One desk keeps them honest.
Membership opens the full screen archive, the composites built from it, and the daily coverage that prices what the screen approves.
Join the deskScreening is research, not a fatwa and not financial advice. Figures are drawn from public accounts at the screen date shown. Always manage your risk.