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Vol. II · No. 256Sunday, 13 September 2026
TTitan Protect
The Screen · Healthcare · Biotechnology

Apogee Therapeutics, Inc. logoApogee Therapeutics, Inc.

APGE · Nasdaq · USD · Market cap $10.2B · 261 employees

Apogee Therapeutics, Inc., a clinical stage biotechnology company, develops novel biologics for the treatment of atopic dermatitis, asthma, eosinophilic esophagitis, chronic obstructive pulmonary disease, and other infla…

Not yet scored
135.07 USD

At the last full screen
2026-09-11

Screened 2026-09-11 · the tape above runs as of 22:12 UTC · 11 Sep · two dates, stated on purpose · verdict and workings shown in full · never trimmed

The Label · The Season, Not the Day

This name holds its accumulation label.

Apogee Therapeutics, Inc. holds its Accumulation at $135.07. The statistical read favours the sellers, held for 35 days.

As held on the ledger · 2026-09-11
PhaseAccumulation
Quantitative stateThe statistical read favours the sellers, held for 35 days
Price at the screen$135.07
ValuationN/A trailing · -26.00 forward price to earnings
Values screenNot scored · score 70.0
Beta0.33
The Workings

Five Screens, Shown in Full

This security has not been fully scored against the values screen yet.

TestFigureLimitWhat it meansStatus
Business activity Permissible Core business clean Its core business isn't built on prohibited lines: no gambling, alcohol, tobacco, weapons, or interest-based lending. Pass
Debt load 0.94% Below 33% Interest-bearing debt is just 0.9% of its assets, well under the one-third ceiling: it does not run on borrowed money. Pass
Interest-bearing cash 18.43% Below 33% Cash held in interest-bearing accounts and securities is 18.4% of assets, under the one-third limit. Pass
Receivables 14.67% Below 49% Money owed to the company is 14.7% of assets, under the 49% limit. Pass
Revenue purity Excluded Below 5% of revenue comes from non-compliant sources, over the 5% line. Fail

Five checks adapted from AAOIFI screening standards: business activity plus four balance-sheet ratios. All five must pass for ethical clearance. Every figure is arithmetic on public accounts, not judgement.

What the Numbers Say It Is Worth

The Fair Value Range

133.00Conservative135.00Base case135.11Growth case 135.07Price

Fair value range in USD, drawn from the 2026-09-11 screen. The gold marker is the market price at the same screen. The price runs 0.1% above the base estimate.

The Street's Range
133.00Street low 135.00Street average 135.11Street high 135.07Price

Third-party analyst targets: 5 covering, consensus Hold. The average target sits −0% from the screen price.

Reading the gap · Our model and the Street both land near today's price: fairly valued, with no strong edge either way.

Price History & Projections
$143$89$35TODAY2y agoPROJECTIONStreet high$135.11 +64%Street avg$135.00 +64%Our fair value$135.00 +64%Conservative$133.00 +61%

Where it has been, where the models see it going. History from market close data; projection points are our fair-value estimates and third-party analyst targets, dated to the 2026-09-11 screen.

Fair value and rating are our own model estimates; the Street's range reflects third-party analyst estimates. Analysis, not advice.

The Business, in Plain Words

Clinical Biotech Priced Near Fair Value

Bringing a new biologic through trials feels like funding a long-shot film that may never reach cinemas. Apogee sits at a clinical stage with zero profit margins and a negative return on equity, yet trades almost exactly at the analysts' median target. The thin margin of safety and complete lack of financial ratio data leave little room to build conviction.

We pass because the ethical screen returns insufficient data and the opportunity rating is none. Negative forward earnings and an unknown moat make any assessment speculative rather than analytical. Without clearer numbers the position stays outside our framework.

Clinical failure, repeated capital raises and binary regulatory outcomes remain the dominant risks. Even a successful trial would still need years of cash burn before any revenue appears. Analysis, not advice.

The fundamentals · plain-English read
Forward P/E-26.0x
EPS, trailing-4.34
EPS, forward-5.20
Profit margin0.0%currently unprofitable
Return on equity-32.5%not currently earning a positive return on equity
FCF yield-1.42%
Debt to equity0.57moderate, manageable leverage
Current ratio26.44comfortably covers its short-term bills
Beta0.33barely tracks the market's swings
Short interest, float0.07%
52-week range35.39 - 135.09
Market cap$10.2B
Employees261

The risks · The things to watch: as a biotechnology name, trial and regulatory outcomes can move it sharply either way.

Plain-English interpretation of our own screen data. Analysis, not advice.

Where & How to Trade

APGE trades on Nasdaq. As a listed security it is accessible through almost any international broker offering its home market. New to this, or investing from abroad? Our guide to accessing global markets covers brokers, currencies and the practical steps.

The Dated Journal · Newest First, Never Edited

Every Entry, As Written

2026-08-21 Accumulation · changed $134.49 +0.4% Entry 6

The framework has shifted from markdown to accumulation since the last review. Smart money appears to be quietly building positions. This typically precedes a markup phase. Price has moved up 0.4% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows excellent risk-adjusted returns. Our composite framework grades it C. Technically it is holding around 18% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 96%. Our forward projection puts the odds of a 10% gain over the next month near 34%. The street (17 analysts) rates it strong buy, with a mean price target of $118. Insiders have been net sellers over the past quarter.

2026-07-21 Markdown $134.00 +51.7% Entry 5

The framework reads markdown. Price is trending lower. Sellers are in control and the prior trend has reversed. Price has moved up 51.7% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows good risk-adjusted returns. Our composite framework grades it C. Technically it is holding around 18% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 96%. Our forward projection puts the odds of a 10% gain over the next month near 34%. The street (17 analysts) rates it strong buy, with a mean price target of $118.

2026-07-18 Markdown $88.33 +0.0% Entry 4

The framework reads markdown. Price is trending lower. Sellers are in control and the prior trend has reversed. Price has moved down 0.0% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows good risk-adjusted returns. Our composite framework grades it C. Technically it is holding around 18% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 96%. Our forward projection puts the odds of a 10% gain over the next month near 34%. The street (17 analysts) rates it strong buy, with a mean price target of $118.

2026-07-17 Markdown $88.33 +0.0% Entry 3

The framework reads markdown. Price is trending lower. Sellers are in control and the prior trend has reversed. Price has moved down 0.0% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows good risk-adjusted returns. Our composite framework grades it C. Technically it is holding around 18% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 96%. Our forward projection puts the odds of a 10% gain over the next month near 34%. The street (17 analysts) rates it strong buy, with a mean price target of $118.

2026-07-03 Markdown $88.33 +0.0% Entry 2

The framework reads markdown. Price is trending lower. Sellers are in control and the prior trend has reversed. Price has moved down 0.0% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows good risk-adjusted returns.

2026-07-02 Markdown $88.33 Entry 1

The framework reads markdown. Price is trending lower. Sellers are in control and the prior trend has reversed. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows good risk-adjusted returns.

Each entry above was written on its date, before the outcome. A journal you can prune is not a journal.

Related Securities · Others in APGE's Space

Screened names in the same industry · explore each on its own page.

The Insider Ledger · Form 4 Filings, As Filed
Most recent filings · APGE
DateInsiderTitleTypeSharesValue
2026-08-05 Dambkowski Carl Chief Medical Officer S - Sale+OE 5,500 $737,935

Public filings, recorded as found. The full tape lives at Insider Intelligence.

The Political Ledger · Congressional Disclosures
Disclosures naming APGE
DatePoliticianPartyTypeAmount
30 Mar2026 Alan Armstrong Republican buy 1K–15K
10 Jul2026 Ro Khanna Democrat sell 1K–15K
What Holding Actually Paid · Price Plus Dividends
If $1,000 had been placed · historical, not a promise
PeriodPrice thenPrice returnDivs per share$1,000 becameTotal return
1 month $84.60 -2.5% · $975 -2.5%
2 months $86.27 -4.4% · $956 -4.4%
3 months $73.51 +12.2% · $1,122 +12.2%
6 months $76.53 +7.7% · $1,077 +7.7%
1 year $42.02 +96.2% · $1,962 +96.2%
2 years $43.90 +87.8% · $1,878 +87.8%

Historical returns from market close data. Past performance does not guarantee future results.

The Ledger's Promise

This entry now belongs to the ledger. Whatever APGE does next, these words stay.

Apogee Therapeutics, Inc. · APGE · Accumulation · $135.07
Recorded 2026-09-11 · before the outcome · scored mechanically

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