The framework has shifted from accumulation to markdown since the last review. Price is trending lower. Sellers are in control and the prior trend has reversed. Price has moved down 8.3% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows modest positive risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is holding around 7% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 22%. Our forward projection puts the odds of a 10% gain over the next month near 28%. The street (9 analysts) rates it strong buy, with a mean price target of $109.
Vaxcyte, Inc.
PCVX · Nasdaq · USD · Market cap $8.3B · 507 employees
Vaxcyte, Inc., a clinical-stage vaccine innovation company, develops conjugate and novel protein vaccines to prevent or treat bacterial infectious diseases.
Not yet scoredScreen close, 2026-10-01 · not a live quote
Last reviewed 4 days ago
Screened 2026-10-01 · the tape above runs as of 07:26 UTC · two dates, stated on purpose · verdict and workings shown in full · never trimmed
What this means: price 56.05 against the desk's fair-value range, base estimate 110.00, over the last year.
- Trend Markdown
- Insiders no filings inside 60 days, left as found
- Positioning no disclosures inside 60 days, left as found
- Options no verdict drawn today, left as found
- Ethical screen not yet scored
Our analytic regime reads on this name, dated and marked against the screened price. Small sample per name, and separate from the daily-framework accuracy on the Track Record page.
This name holds its markdown label.
Vaxcyte, Inc. holds its Markdown at $56.05. Consolidating, no directional conviction, held for 236 days.
| Phase | Markdown · caution |
| Quantitative state | Consolidating, no directional conviction, held for 236 days |
| Price at the screen | $56.05 |
| Valuation | N/A trailing · -7.77 forward price to earnings |
| Values screen | Not scored · score 70.0 |
| Beta | 1.22 |
Five Screens, Shown in Full
This security has not been fully scored against the values screen yet.
| Test | Figure | Limit | What it means | Status |
|---|---|---|---|---|
| Business activity | Permissible | Core business clean | Its core business isn't built on prohibited lines: no gambling, alcohol, tobacco, weapons, or interest-based lending. | Pass |
| Debt load | 3.91% | Below 33% | Interest-bearing debt is just 3.9% of its assets, well under the one-third ceiling: it does not run on borrowed money. | Pass |
| Interest-bearing cash | 29.36% | Below 33% | Cash held in interest-bearing accounts and securities is 29.4% of assets, under the one-third limit. | Pass |
| Receivables | 5.79% | Below 49% | Money owed to the company is 5.8% of assets, under the 49% limit. | Pass |
| Revenue purity | Excluded | Below 5% | of revenue comes from non-compliant sources, over the 5% line. | Fail |
Five checks adapted from AAOIFI screening standards: business activity plus four balance-sheet ratios. All five must pass for ethical clearance. Every figure is arithmetic on public accounts, not judgement.
The Ethical ReadThe Read, in Plain English
Vaxcyte, clears the business-activity screen and the figures we can measure look clean, but its income-purity figure is still pending, so the verdict is not final yet.
Read as at 2026-10-04. It updates when the underlying figures move, and past reads are kept below.
What the Numbers Say It Is WorthThe Fair Value Range
Fair value range in USD, drawn from the 2026-10-01 screen. The gold marker is the market price at the same screen. A 96.3% margin of safety to the base estimate.
Third-party analyst targets: 9 covering, consensus Strong Buy. The average target sits +96% from the screen price.
Reading the gap · Both our model and the analysts see meaningful upside from here.
Price History & ProjectionsWhere it has been, where the models see it going. History from market close data; projection points are our fair-value estimates and third-party analyst targets, dated to the 2026-10-01 screen.
Fair value and rating are our own model estimates; the Street's range reflects third-party analyst estimates. Analysis, not advice.
The Business, in Plain WordsClinical Vaccine Hopes Meet Missing Numbers
Picture a lab racing to build a 24-strain pneumonia shot that could protect millions, yet the books behind the effort stay half blank. Vaxcyte sits at that stage, still burning cash with zero profit margin and a negative 31 percent return on equity. The market prices the shares well below our calculated fair value, yet the ethical screen flags insufficient data and blocks any further look.
We pass because the numbers required to judge durability simply are not there. No clear moat, no earnings history and no financial ratios that would let us test the story against real cash flow. Analyst targets may cluster higher, but without the basic data the screen demands we stay on the sidelines.
Biotech pipelines carry binary trial outcomes and long cash drains that can wipe out value overnight. Currency swings and dilution risk add further pressure when profits remain years away at best. Analysis, not advice.
| Forward P/E | -7.8x |
| EPS, trailing | -7.63 |
| EPS, forward | -7.22 |
| Profit margin | 0.0%currently unprofitable |
| Return on equity | -36.5%not currently earning a positive return on equity |
| FCF yield | -5.82% |
| Debt to equity | 4.19heavy leverage: higher risk if revenue softens |
| Current ratio | 5.72comfortably covers its short-term bills |
| Beta | 1.22moves a little more than the market |
| Short interest, float | 0.11% |
| 52-week range | 37.69 - 65.00 |
| Market cap | $8.3B |
| Employees | 507 |
The risks · The things to watch: as a biotechnology name, trial and regulatory outcomes can move it sharply either way; it carries a real debt load, which raises the stakes if revenue slips.
Plain-English interpretation of our own screen data. Analysis, not advice.
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Every Entry, As Written
The framework has shifted from markup to accumulation since the last review. Smart money appears to be quietly building positions. This typically precedes a markup phase. Price has moved up 3.7% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows modest positive risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is holding around 7% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 22%. Our forward projection puts the odds of a 10% gain over the next month near 28%. The street (9 analysts) rates it strong buy, with a mean price target of $109.
The framework has shifted from distribution to markup since the last review. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Price has moved up 24.1% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows modest positive risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is holding around 7% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 22%. Our forward projection puts the odds of a 10% gain over the next month near 28%. The street (9 analysts) rates it strong buy, with a mean price target of $109.
The framework reads distribution. Smart money appears to be selling into strength. Institutional holders may be rotating out. Price has moved down 0.0% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows modest positive risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is holding around 7% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 22%. Our forward projection puts the odds of a 10% gain over the next month near 28%. The street (9 analysts) rates it strong buy, with a mean price target of $109.
The framework reads distribution. Smart money appears to be selling into strength. Institutional holders may be rotating out. Price has moved down 0.0% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows modest positive risk-adjusted returns.
The framework reads distribution. Smart money appears to be selling into strength. Institutional holders may be rotating out. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows modest positive risk-adjusted returns.
Each entry above was written on its date, before the outcome. A journal you can prune is not a journal.
- Vaxcyte (PCVX) Brings In Pharma Veterans As Its Big Test Nears Insider Monkey · 18d ago
- Vaxcyte Has $2.5 Billion in Cash and a $605 Million Half-Year Loss. Here's How to Read Its CFO's Latest Insider Filing Motley Fool · 27d ago
- A Vaxcyte Executive Just Cashed Options Struck at $5.35. Here's What Long-Term Investors Should Know Motley Fool · 27d ago
- Vaxcyte's CEO Parted With Shares for Taxes. Here's What Long-Term Investors Should Know About the Firm Motley Fool · 27d ago
- The Next Year Will Define Vaxcyte’s (PCVX) Vaccine Gamble Insider Monkey · 29d ago
Headlines from third-party outlets, linked for reference: not our reporting, not advice.
Screened names in the same industry · explore each on its own page.
| Date | Politician | Party | Type | Amount |
|---|---|---|---|---|
| 2026-06-15 | David Taylor | Republican | buy | 1K–15K |
| 2025-02-07 | Tim Walberg | Republican | buy | 15K–50K |
| Period | Price then | Price return | Divs per share | $1,000 became | Total return |
|---|---|---|---|---|---|
| 1 month | $53.99 | -15.7% | · | $843 | -15.7% |
| 2 months | $60.88 | -25.3% | · | $748 | -25.3% |
| 3 months | $56.21 | -19.0% | · | $810 | -19.0% |
| 6 months | $44.59 | +2.1% | · | $1,021 | +2.1% |
| 1 year | $37.20 | +22.3% | · | $1,223 | +22.3% |
| 2 years | $71.88 | -36.7% | · | $633 | -36.7% |
| 3 years | $50.56 | -10.0% | · | $900 | -10.0% |
| 5 years | $22.01 | +106.8% | · | $2,068 | +106.8% |
Historical returns from market close data. Past performance does not guarantee future results.
This entry now belongs to the ledger. Whatever PCVX does next, these words stay.
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Join the deskScreening is research, not a fatwa and not financial advice. Figures are drawn from public accounts at the screen date shown. Always manage your risk.