PTGX
Protagonist Therapeutics, Inc.
Healthcare · Biotechnology · NGM
$97.38
Data: 2026-05-28
✓ ETHICAL PASS

Unknown MOAT
HIGH
Data Confidence: 85.7%
Key Metrics

How this company measures up on the fundamentals that matter

Market Cap
$6.6B
Total market value of the company
-149.29
Based on estimated future earnings — lower means cheaper
Rev Growth
+99.0%
Year-over-year revenue change
Profit Margin
-154.9%
How much profit the company keeps from each dollar of revenue
-17.1%
Return on equity — how efficiently it uses shareholder money
Analyst Target
$118.00
+21% from current price — median analyst estimate
Recommendation
STRONG_BUY
Consensus view from 13 analysts covering this stock
About Protagonist Therapeutics, Inc.

Protagonist Therapeutics, Inc. operates as a discovery and development company in the United States. It develops Icotyde, a first-in-class investigational targeted oral peptide for the treatment of adults and pediatric patients 12 years of age and older with moderate-to-severe plaque psoriasis; and Rusfertide, a first-in-class investigational injectable mimetic of the natural hormone hepcidin in Phase 3 development for the treatment of the rare blood disorder polycythemia vera. The company is also developing PN-881, a potential best-in-class oral peptide IL-17 antagonist, for the treatment of immune-mediated skin diseases in Phase 1 clinical trials; PN-477 and PN-458, which are development candidates for the treatment of obesity; PN-8047, an orally administered hepcidin functional mimetic small molecule; L-4R alpha antagonist for the treatment of atopic dermatitis and moderate-to-severe asthma; and amylinR-based oral and subcutaneous mono- and poly-agonists for the treatment of obesity. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.

https://www.protagonist-inc.com

Country: United States Employees: 131 Industry: Biotechnology
Ethical Screening

Five compliance checks based on AAOIFI standards — all must pass for ethical clearance

Business Activity
PASS
Core business does not involve prohibited activities
Debt Ratio
0.0% N/A
Debt must be below 33% of total assets
Cash Ratio
0.0% N/A
Interest-bearing cash below 33% of assets
Receivables
0.0% N/A
Receivables below 49% of assets
Revenue Purity
0.0% PASS
Non-compliant revenue below 5% — any excess requires purification
Quantitative Intelligence

Statistical analysis of price behaviour, risk, and market regime — independent of fundamental data

MARKUP
Price trending up with increasing momentum
1.379
Excellent risk-adjusted returns
0.1301
Suggested allocation is meaningful — the edge justifies a position
2.867
Returns exceed worst-case losses — strong risk profile
Annual Return
90.5%
Historical annualised return based on price data
-31.6%
Largest peak-to-trough decline — the worst it has been
SIDEWAYS
Price consolidating — no clear directional bias
Days in State
137
How long the current regime has persisted — longer means more stable
Market Data

Trading characteristics and market positioning

1.88
Significantly more volatile than the market
52W High
$107.84
10% below the year high
52W Low
$45.43
114% above the year low
Avg Volume
735,568
Average daily shares traded — higher means easier to buy and sell
11.8
Days it would take all short sellers to cover — higher means more crowded
Short % Float
13.2%
Elevated short interest — bears are positioned against this
N/A
Annual dividend as a percentage of the share price
$-1.81
Earnings per share over the last 12 months
Financial Health

Balance sheet strength and cash generation — the foundation of long-term value

1.49
Meaningful debt load — monitor closely
17.76
Strong balance sheet — comfortably covers short-term obligations
Quick Ratio
17.51
Like current ratio but excludes inventory — stricter test
Gross Margin
100.0%
Revenue left after cost of goods — higher means pricing power
Operating Margin
-6.5%
Profit from core operations before interest and tax
$-77,664,624
Negative — the business is spending more than it generates
Revenue (TTM)
$74M
Total revenue over the last 12 months
Net Income
$-114,711,000
Loss-making — spending exceeds revenue after all costs
Analyst Coverage
Analysts
13
Target High
$137.00
Target Median
$118.00
Target Low
$100.00
Explore the Ethical Screener View Track Record

Data sourced from public filings and market feeds. Not financial advice. Updated: 2026-05-28

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