Framework Journal · one stock, one dated entry

Recorded 2026-07-30 · Permanent

Arrowhead Pharmaceuticals Inc logoArrowhead Pharmaceuticals Inc ARWR

Clears both ethical standards

An entry written while the outcome is still unknown. It will be scored by what the market does next, and it will never be edited to look cleverer than it was.

In plain words · Arrowhead Pharmaceuticals, Inc.

The label
Markup

read at $87.32

Arrowhead Pharmaceuticals Inc holds its Markup at $87.32.

PHINPOOPSC
  • PHPhase · the trend structure carries the Markup label
  • INInsiders · no filings inside 60 days, left as found
  • POPositioning · no disclosures inside 60 days, left as found
  • OPOptions · no verdict drawn today, left as found
  • SCScreen · passes the values gate
  • edge confirmed
  • edge broken
  • edge forming

Each arm is one independent read. Conviction is not a single call, it is how many edges converge.

The investor read · the season, not the day

As held on the ledger · 2026-07-30
PhaseMarkup
Quantitative stateThe statistical read favours the sellers, held for 108 days
Price$87.32
ValuationN/A trailing · -19.14 forward price to earnings
Values screenPASS · score 70.0
Beta1.27

The opportunity · what the numbers say it is worth

Read at
$87.32
N/A P/E · -19.14 fwd
Our fair value
$100.00
15% discount
Analyst target (avg)
$100.00
+15% to current
Target low $95.00Analyst target rangeTarget high $126.00
▲ current $87.32 · | average target

Price history & projections · where it has been, where the models see it going

$135$71$8TODAY5y agoPROJECTIONAnalyst high$126.00 +78%Analyst avg$100.00 +41%Our fair value$100.00 +41%Conservative$95.00 +34%

The valuation journey · where the price sits against fair value and the Street

Current
$87.32
you are here
Conservative
$95.00
+9%
Analyst avg
$100.00
+15%
Our fair value
$100.00
+15%
Analyst high
$126.00
+44%

Green marks levels above today's price, red below; the shaded band is the gap between the price and our fair value.

Reading the gap · Both our model and the analysts see meaningful upside from here.

Revenue growth-86.40%
Profit margin-48.38%
Debt to equity231.05
Analyst consensusStrong Buy · 11 covering

Fair value and rating are our own model estimates; target range reflects third-party analyst estimates. Analysis, not advice.

The values screen, explained · five checks, plain English

This company clears both standards. There are two widely recognised ways to check whether a company is suitable for a Muslim investor. Here is how it did on each:

The common standard · AAOIFI
Used by most halal investing apps
✓ PASSES
Our stricter standard · asset-based
The one Titan applies
✓ PASSES

What these two standards are, and how they differ →

  • Business activity Its core business isn't built on prohibited lines — no gambling, alcohol, tobacco, weapons, or interest-based lending. Pass
  • Debt load Interest-bearing debt is of its assets, above the one-third ceiling the screen allows. Fail
  • Interest-bearing cash Interest-bearing cash and securities are of assets, above the one-third limit. Fail
  • Receivables Money owed to the company is of assets, above the 49% limit. Fail
  • Revenue purity of revenue comes from non-compliant sources, over the 5% line. Fail

Every security is read against two recognised standards: our stricter asset-based screen (ratios measured against total assets) and the more widely used market-value standard (measured against market capitalisation). Where they agree we say so plainly; where they part ways — almost always on the debt check — we show both readings and mark it, because that disagreement is the finding, not a fault. We report the score; you and your scholar make the call.

The business, in plain words · what the numbers mean

Biotech Hopes Clash With Shrinking Revenue

Picture a lab racing to turn early drug trials into real medicines while sales collapse. Arrowhead develops RNA based treatments for stubborn diseases, yet its latest numbers show revenue down 86 percent and a 48 percent loss margin. Analysts still cluster around a 97 dollar target, but our reading sees no edge worth taking.

The business carries a weak moat, negative return on equity of 42 percent, and a forward multiple that reflects deep losses rather than growth. Even with an ethical pass and a listed margin of safety to 97 dollars, the opportunity rating stays at none because the underlying metrics point to execution risk, not value.

Clinical setbacks remain the norm in this field, and a single failed Phase 3 study can wipe out years of work. Currency moves or funding squeezes add further pressure on a company already burning cash. Analysis, not advice.

The fundamentals · plain-English read
Forward P/E-19.1x
Revenue growth-86.4%
revenue is shrinking
Profit margin-48.4%
currently unprofitable
Return on equity-42.4%
not currently earning a positive return on equity
Debt to equity2.31
heavy leverage — higher risk if revenue softens
Current ratio6.23
comfortably covers its short-term bills
Beta1.27
moves a little more than the market
Market cap$12.3B
Employees711

The risks · The things to watch: as a biotechnology name, trial and regulatory outcomes can move it sharply either way; it carries a real debt load, which raises the stakes if revenue slips.

Plain-English interpretation of our own screen data. Analysis, not advice.

Related securities · others in ARWR's space worth a look

Screened names in the same industry · explore each on its own page.

The trader read · the latest dated commentary

The framework reads distribution. Smart money appears to be selling into strength. Institutional holders may be rotating out. Price has moved down 0.3% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows excellent risk-adjusted returns. Our composite framework grades it D. Technically it is holding around 36% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 318%. Our forward projection puts the odds of a 10% gain over the next month near 40%. The street (12 analysts) rates it buy, with a mean price target of $89. Entered 2026-07-21 · Distribution

The dated journal · newest first, never edited

2026-07-21 Distribution $74.30 -0.3% Entry 5

The framework reads distribution. Smart money appears to be selling into strength. Institutional holders may be rotating out. Price has moved down 0.3% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows excellent risk-adjusted returns. Our composite framework grades it D. Technically it is holding around 36% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 318%. Our forward projection puts the odds of a 10% gain over the next month near 40%. The street (12 analysts) rates it buy, with a mean price target of $89.

2026-07-18 Distribution $74.52 +0.0% Entry 4

The framework reads distribution. Smart money appears to be selling into strength. Institutional holders may be rotating out. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows excellent risk-adjusted returns. Our composite framework grades it D. Technically it is holding around 36% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 318%. Our forward projection puts the odds of a 10% gain over the next month near 40%. The street (12 analysts) rates it buy, with a mean price target of $89.

2026-07-17 Distribution $74.52 +0.0% Entry 3

The framework reads distribution. Smart money appears to be selling into strength. Institutional holders may be rotating out. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen (70). The risk-adjusted return profile shows excellent risk-adjusted returns. Our composite framework grades it D. Technically it is holding around 36% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 318%. Our forward projection puts the odds of a 10% gain over the next month near 40%. The street (12 analysts) rates it buy, with a mean price target of $89.

2026-07-03 Distribution $74.52 +0.0% Entry 2

The framework reads distribution. Smart money appears to be selling into strength. Institutional holders may be rotating out. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen (70). The risk-adjusted return profile shows excellent risk-adjusted returns.

2026-07-02 Distribution $74.52 Entry 1

The framework reads distribution. Smart money appears to be selling into strength. Institutional holders may be rotating out. Ethical screening: PASS with passing ethical screen (70). The risk-adjusted return profile shows excellent risk-adjusted returns.

Each entry above was written on its date, before the outcome. A journal you can prune is not a journal.

What holding actually paid · price plus dividends

If $1,000 had been placed · historical, not a promise
PeriodPrice thenPrice returnDivs per share$1,000 becameTotal return
1 month $77.74 -8.8% · $912 -8.8%
2 months $65.14 +8.9% · $1,089 +8.9%
3 months $55.01 +28.9% · $1,289 +28.9%
6 months $70.82 +0.1% · $1,001 +0.1%
1 year $16.97 +317.9% · $4,179 +317.9%
2 years $24.51 +189.3% · $2,893 +189.3%
3 years $35.32 +100.8% · $2,008 +100.8%
5 years $88.71 -20.1% · $799 -20.1%

Historical returns from market close data. Past performance does not guarantee future results.

This entry now belongs to the ledger. Whatever ARWR does next, these words stay.

Arrowhead Pharmaceuticals Inc · ARWR · Markup · $87.32
Recorded 2026-07-30 · before the outcome · scored mechanically

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