Framework Journal · one stock, one dated entry

Recorded 2026-08-13 · Permanent

Axsome Therapeutics Inc logoAxsome Therapeutics Inc AXSM

Outside both standards

An entry written while the outcome is still unknown. It will be scored by what the market does next, and it will never be edited to look cleverer than it was.

In plain words · Axsome Therapeutics, Inc., a biopharmaceutical company, develops and delivers novel therapies for the management of central nervous system (CNS) disorders in the United States.

The label
Distribution

read at $213.68

Axsome Therapeutics Inc holds its Distribution at $213.68.

PHINPOOPSC
  • PHPhase · the trend structure carries the Distribution label
  • INInsiders · insiders sold, $10,538,305, latest filing 2026-08-05
  • POPositioning · no disclosures inside 60 days, left as found
  • OPOptions · no verdict drawn today, left as found
  • SCScreen · does not pass the values gate
  • edge confirmed
  • edge broken
  • edge forming

Each arm is one independent read. Conviction is not a single call, it is how many edges converge.

The investor read · the season, not the day

As held on the ledger · 2026-08-13
PhaseDistribution · caution
Quantitative stateThe statistical read favours the sellers, held for 5 days
Price$213.68
ValuationN/A trailing · 41.99 forward price to earnings
Values screenFAIL · score 70.0
Beta0.73

The opportunity · what the numbers say it is worth

Read at
$213.68
N/A P/E · 41.99 fwd
Our fair value
$193.98
9% premium
Analyst target (avg)
$276.00
+29% to current
Target low $246.00Analyst target rangeTarget high $380.00
▲ current $213.68 · | average target

Price history & projections · where it has been, where the models see it going

$405$223$41TODAY5y agoPROJECTIONAnalyst high$380.00 +53%Analyst avg$276.00 +11%Conservative$193.98 -22%Our fair value$193.98 -22%

The valuation journey · where the price sits against fair value and the Street

Current
$213.68
you are here
Conservative
$193.98
-9%
Analyst avg
$276.00
+29%
Our fair value
$193.98
-9%
Analyst high
$380.00
+78%

Green marks levels above today's price, red below; the shaded band is the gap between the price and our fair value.

Reading the gap · Our more conservative model reads it as fully-to-richly valued here, while the Street is more bullish — a quality-at-a-fair-price name rather than a deep-value one.

Revenue growth45.50%
Profit margin-24.68%
Debt to equity269.73
Analyst consensusStrong Buy · 21 covering

Fair value and rating are our own model estimates; target range reflects third-party analyst estimates. Analysis, not advice.

The values screen, explained · five checks, plain English

This company is excluded by both standards. There are two widely recognised ways to check whether a company is suitable for a Muslim investor. It fails on both:

The common standard · AAOIFI
Used by most halal investing apps
✗ DOES NOT PASS
Our stricter standard · asset-based
The one Titan applies
✗ DOES NOT PASS

Why it fails. The problem is its accounts receivable. Because both standards agree on this, it is a clear exclusion, not a borderline case.

What these two standards are, and how they differ →

  • Business activity Its core business isn't built on prohibited lines — no gambling, alcohol, tobacco, weapons, or interest-based lending. Pass
  • Debt load Interest-bearing debt is just 31.6% of its assets, well under the one-third ceiling — it does not run on borrowed money. Pass
  • Interest-bearing cash Cash held in interest-bearing accounts and securities is 0.0% of assets, under the one-third limit. Pass
  • Receivables Money owed to the company is 79.4% of assets, above the 49% limit. Fail
  • Revenue purity Only 0.0% of revenue comes from non-compliant sources — under the 5% line. Pass

Every security is read against two recognised standards: our stricter asset-based screen (ratios measured against total assets) and the more widely used market-value standard (measured against market capitalisation). Where they agree we say so plainly; where they part ways — almost always on the debt check — we show both readings and mark it, because that disagreement is the finding, not a fault. We report the score; you and your scholar make the call.

The business, in plain words · what the numbers mean

New CNS Drug Hits Market Yet Losses Mount

Picture a patient in need of fresh CNS relief and a company racing to deliver it. Axsome brings Auvelity to market with revenue climbing 57 percent, yet it still posts a 27 percent negative profit margin and a startling negative 349 percent return on equity.

We pass. The shares trade at 230 dollars against a 201 dollar fair value, a forward multiple of 39 times earnings, and no margin of safety. Narrow moat plus ongoing cash burn leaves little room for error despite the strong buy chorus from analysts.

Risk sits in the valuation itself. Any slip in uptake or fresh clinical setbacks would punish the premium price quickly in a sector where profits remain distant. Analysis, not advice.

The fundamentals · plain-English read
Forward P/E42.0x
fairly priced for its growth rate
Revenue growth45.5%
growing very fast
Profit margin-24.7%
currently unprofitable
Return on equity-245.1%
not currently earning a positive return on equity
Debt to equity2.70
heavy leverage — higher risk if revenue softens
Current ratio1.43
adequate liquidity, worth monitoring
Beta0.73
steadier than the market
Market cap$11.2B
Employees1,220

The risks · The things to watch: as a biotechnology name, trial and regulatory outcomes can move it sharply either way; it carries a real debt load, which raises the stakes if revenue slips.

Plain-English interpretation of our own screen data. Analysis, not advice.

Related securities · others in AXSM's space worth a look

Screened names in the same industry · explore each on its own page.

The trader read · the latest dated commentary

The framework reads markup. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Price has moved down 9.9% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows excellent risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is holding around 43% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 125%. Our forward projection puts the odds of a 10% gain over the next month near 39%. The street (21 analysts) rates it strong buy, with a mean price target of $276. Entered 2026-07-22 · Markup

The dated journal · newest first, never edited

2026-07-22 Markup $230.00 -9.9% Entry 4

The framework reads markup. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Price has moved down 9.9% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows excellent risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is holding around 43% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 125%. Our forward projection puts the odds of a 10% gain over the next month near 39%. The street (21 analysts) rates it strong buy, with a mean price target of $276.

2026-07-18 Markup $255.17 +0.0% Entry 3

The framework reads markup. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen (70). The risk-adjusted return profile shows excellent risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is holding around 43% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 125%. Our forward projection puts the odds of a 10% gain over the next month near 39%. The street (21 analysts) rates it strong buy, with a mean price target of $276.

2026-07-03 Markup $255.17 +0.0% Entry 2

The framework reads markup. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen (70). The risk-adjusted return profile shows excellent risk-adjusted returns.

2026-07-02 Markup $255.17 Entry 1

The framework reads markup. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Ethical screening: PASS with passing ethical screen (70). The risk-adjusted return profile shows excellent risk-adjusted returns.

Each entry above was written on its date, before the outcome. A journal you can prune is not a journal.

The insider ledger · Form 4 filings, as filed

Most recent filings · AXSM
DateInsiderTitleTypeSharesValue
2026-08-05 Tabuteau Herriot CEO, 10% S - Sale+OE 49,664 $10,538,305

Public filings, recorded as found. The full tape lives at Insider Intelligence.

What holding actually paid · price plus dividends

If $1,000 had been placed · historical, not a promise
PeriodPrice thenPrice returnDivs per share$1,000 becameTotal return
1 month $216.47 +14.5% · $1,145 +14.5%
2 months $178.11 +39.1% · $1,391 +39.1%
3 months $154.12 +60.8% · $1,608 +60.8%
6 months $148.75 +66.6% · $1,666 +66.6%
1 year $109.91 +125.5% · $2,255 +125.5%
2 years $71.80 +245.1% · $3,451 +245.1%
3 years $73.74 +236.1% · $3,361 +236.1%
5 years $66.39 +273.3% · $3,733 +273.3%

Historical returns from market close data. Past performance does not guarantee future results.

This entry now belongs to the ledger. Whatever AXSM does next, these words stay.

Axsome Therapeutics Inc · AXSM · Distribution · $213.68
Recorded 2026-08-13 · before the outcome · scored mechanically

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