The framework has shifted from markup to accumulation since the last review. Smart money appears to be quietly building positions. This typically precedes a markup phase. Price has moved down 2.9% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows excellent risk-adjusted returns. Our composite framework grades it B, carrying a low risk profile. Technically it is holding around 34% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 126%. Our forward projection puts the odds of a 10% gain over the next month near 33%. The street (9 analysts) rates it strong buy, with a mean price target of $323. Insiders have been net sellers over the past quarter.
Krystal Biotech, Inc.
KRYS · Nasdaq · USD · Market cap $10.3B · 295 employees
Krystal Biotech, Inc., a commercial-stage biotechnology company, discovers, develops, manufactures, and commercializes genetic medicines to treat diseases with high unmet medical needs in the United States.
FAIL · Does not pass the screenAt the last full screen
2026-09-11
Screened 2026-09-11 · the tape above runs as of 22:12 UTC · 11 Sep · two dates, stated on purpose · verdict and workings shown in full · never trimmed
This name holds its accumulation label.
Krystal Biotech, Inc. holds its Accumulation at $347.00. Consolidating, no directional conviction, held for 205 days.
| Phase | Accumulation |
| Quantitative state | Consolidating, no directional conviction, held for 205 days |
| Price at the screen | $347.00 |
| Valuation | 43.48 trailing · 36.92 forward price to earnings |
| Values screen | FAIL · score 70.0 |
| Beta | 0.54 |
Five Screens, Shown in Full
Does not pass. Revenue purity
| Test | Figure | Limit | What it means | Status |
|---|---|---|---|---|
| Business activity | Permissible | Core business clean | Its core business isn't built on prohibited lines: no gambling, alcohol, tobacco, weapons, or interest-based lending. | Pass |
| Debt load | 0.70% | Below 33% | Interest-bearing debt is just 0.7% of its assets, well under the one-third ceiling: it does not run on borrowed money. | Pass |
| Interest-bearing cash | 9.60% | Below 33% | Cash held in interest-bearing accounts and securities is 9.6% of assets, under the one-third limit. | Pass |
| Receivables | 46.76% | Below 49% | Money owed to the company is 46.8% of assets, under the 49% limit. | Pass |
| Revenue purity | 7.24% | Below 5% | 7.2% of revenue comes from non-compliant sources, over the 5% line. | Fail |
Five checks adapted from AAOIFI screening standards: business activity plus four balance-sheet ratios. All five must pass for ethical clearance. Every figure is arithmetic on public accounts, not judgement.
What the Numbers Say It Is WorthThe Fair Value Range
Fair value range in USD, drawn from the 2026-09-11 screen. The gold marker is the market price at the same screen. The price runs 14.2% above the base estimate.
Third-party analyst targets: 8 covering, consensus None. The average target sits +12% from the screen price.
Reading the gap · Our more conservative model reads it as fully-to-richly valued here, while the Street is more bullish: a quality-at-a-fair-price name rather than a deep-value one.
Price History & ProjectionsWhere it has been, where the models see it going. History from market close data; projection points are our fair-value estimates and third-party analyst targets, dated to the 2026-09-11 screen.
Fair value and rating are our own model estimates; the Street's range reflects third-party analyst estimates. Analysis, not advice.
The Business, in Plain WordsOne approved gene fix, yet priced for perfection
Krystal Biotech sells a single gene therapy that treats a rare and painful skin disorder with one dose. The product already drives 32 percent revenue growth and a 54 percent profit margin, yet the shares sit 16 percent above our fair value at a 35 times forward earnings multiple.
We pass because the current price leaves no margin of safety. Strong analyst targets and clean ethical marks cannot offset the fact that investors are paying a premium for a company with just one commercial asset and an unknown competitive moat.
The main risk is simple: any delay in new pipeline launches or pressure on pricing would hit earnings hard at this valuation. Peak earnings and a high multiple together often signal a trap rather than an opportunity. Analysis, not advice.
| Forward P/E | 36.9xpriced for continued growth |
| Trailing P/E | 43.5xexpensive: the price assumes strong growth ahead |
| EPS, trailing | 7.98 |
| EPS, forward | 9.40 |
| Revenue growth | +24.1%strong top-line growth |
| Profit margin | 54.8%highly profitable on every dollar of sales |
| Return on equity | 20.1%an exceptional return on shareholder capital |
| FCF yield | 1.48% |
| Debt to equity | 0.65moderate, manageable leverage |
| Current ratio | 8.32comfortably covers its short-term bills |
| Beta | 0.54steadier than the market |
| Short interest, float | 0.19% |
| 52-week range | 141.25 - 382.54 |
| Market cap | $10.3B |
| Employees | 295 |
The risks · The things to watch: as a biotechnology name, trial and regulatory outcomes can move it sharply either way.
Plain-English interpretation of our own screen data. Analysis, not advice.
Where & How to TradeKRYS trades on Nasdaq. As a listed security it is accessible through almost any international broker offering its home market. New to this, or investing from abroad? Our guide to accessing global markets covers brokers, currencies and the practical steps.
Every Entry, As Written
The framework reads markup. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Price has moved up 15.4% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows excellent risk-adjusted returns. Our composite framework grades it B, carrying a low risk profile. Technically it is holding around 34% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 126%. Our forward projection puts the odds of a 10% gain over the next month near 33%. The street (9 analysts) rates it strong buy, with a mean price target of $323.
The framework reads markup. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows excellent risk-adjusted returns. Our composite framework grades it B, carrying a low risk profile. Technically it is holding around 34% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 126%. Our forward projection puts the odds of a 10% gain over the next month near 33%. The street (9 analysts) rates it strong buy, with a mean price target of $323.
The framework reads markup. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen (70). The risk-adjusted return profile shows excellent risk-adjusted returns.
The framework reads markup. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Ethical screening: PASS with passing ethical screen (70). The risk-adjusted return profile shows excellent risk-adjusted returns.
Each entry above was written on its date, before the outcome. A journal you can prune is not a journal.
Screened names in the same industry · explore each on its own page.
| Date | Insider | Title | Type | Shares | Value |
|---|---|---|---|---|---|
| 2026-08-14 | Rossi Dino A | Dir | S - Sale | 25,000 | $8,227,953 |
Public filings, recorded as found. The full tape lives at Insider Intelligence.
| Period | Price then | Price return | Divs per share | $1,000 became | Total return |
|---|---|---|---|---|---|
| 1 month | $312.88 | -0.4% | · | $997 | -0.4% |
| 2 months | $259.00 | +20.4% | · | $1,204 | +20.4% |
| 3 months | $251.31 | +24.1% | · | $1,241 | +24.1% |
| 6 months | $246.77 | +26.3% | · | $1,263 | +26.3% |
| 1 year | $138.21 | +125.6% | · | $2,256 | +125.6% |
| 2 years | $176.83 | +76.3% | · | $1,763 | +76.3% |
| 3 years | $128.92 | +141.8% | · | $2,418 | +141.8% |
| 5 years | $65.05 | +379.3% | · | $4,793 | +379.3% |
Historical returns from market close data. Past performance does not guarantee future results.
This entry now belongs to the ledger. Whatever KRYS does next, these words stay.
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