The framework has shifted from markup to distribution since the last review. Smart money appears to be selling into strength. Institutional holders may be rotating out. Price has moved up 2.2% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows excellent risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is holding around 15% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 75%. Our forward projection puts the odds of a 10% gain over the next month near 40%. The street (13 analysts) rates it none, with a mean price target of $40.
Zymeworks Inc.
ZYME · Nasdaq · USD · Market cap $2.0B · 243 employees
Zymeworks Inc., a biotechnology company, develops biotherapeutics for the treatment of cancer, inflammation, and autoimmune diseases.
FAIL · Does not pass the screenScreen close, 2026-09-21 · not a live quote
Last reviewed 14 days ago
Screened 2026-09-21 · the tape above runs as of 09:01 UTC · two dates, stated on purpose · verdict and workings shown in full · never trimmed
What this means: price 26.81 against the desk's fair-value range, base estimate 24.75, over the last year.
- Trend Markdown
- Insiders no filings inside 60 days, left as found
- Positioning no disclosures inside 60 days, left as found
- Options no verdict drawn today, left as found
- Ethical does not pass the values gate
Our analytic regime reads on this name, dated and marked against the screened price. Small sample per name, and separate from the daily-framework accuracy on the Track Record page.
This name holds its markdown label.
Zymeworks Inc. holds its Markdown at $26.81. The statistical read favours the sellers, held for 14 days.
| Phase | Markdown · caution |
| Quantitative state | The statistical read favours the sellers, held for 14 days |
| Price at the screen | $26.81 |
| Valuation | N/A trailing · 22.98 forward price to earnings |
| Values screen | FAIL · score 70.0 |
| Beta | 1.19 |
Five Screens, Shown in Full
Does not pass. Interest-bearing securities
| Test | Figure | Limit | What it means | Status |
|---|---|---|---|---|
| Business activity | Permissible | Core business clean | Its core business isn't built on prohibited lines: no gambling, alcohol, tobacco, weapons, or interest-based lending. | Pass |
| Debt load | 5.27% | Below 33% | Interest-bearing debt is just 5.3% of its assets, well under the one-third ceiling: it does not run on borrowed money. | Pass |
| Interest-bearing cash | 54.15% | Below 33% | Interest-bearing cash and securities are 54.1% of assets, above the one-third limit. | Fail |
| Receivables | 13.22% | Below 49% | Money owed to the company is 13.2% of assets, under the 49% limit. | Pass |
| Revenue purity | 12.60% | Below 5% | 12.6% of revenue comes from non-compliant sources, over the 5% line. | Fail |
Five checks adapted from AAOIFI screening standards: business activity plus four balance-sheet ratios. All five must pass for ethical clearance. Every figure is arithmetic on public accounts, not judgement.
The Ethical ReadWhy It Falls Short, in Plain English
Zymeworks's business is fine, but its cash and interest-bearing securities are about 54% of its assets, well over the ~33% line, so it does not pass on the financial screens.
Read as at 2026-10-04. It updates when the underlying figures move, and past reads are kept below.
What the Numbers Say It Is WorthThe Fair Value Range
Fair value range in USD, drawn from the 2026-09-21 screen. The gold marker is the market price at the same screen. The price runs 7.7% above the base estimate.
Third-party analyst targets: 12 covering, consensus Strong Buy. The average target sits +45% from the screen price.
Reading the gap · Our more conservative model reads it as fully-to-richly valued here, while the Street is more bullish: a quality-at-a-fair-price name rather than a deep-value one.
Price History & ProjectionsWhere it has been, where the models see it going. History from market close data; projection points are our fair-value estimates and third-party analyst targets, dated to the 2026-09-21 screen.
Fair value and rating are our own model estimates; the Street's range reflects third-party analyst estimates. Analysis, not advice.
The Business, in Plain WordsBiotech Pipeline Hits Revenue Freefall Wall
Picture a lab racing to craft the next cancer fighter while the cash register rings up losses instead of sales. Zymeworks builds antibody platforms for tough diseases yet just posted revenue growth of minus 91 percent and a profit margin of minus 126 percent. At 24 dollars against our fair value of 20 dollars the shares already price in miracles that the current numbers do not support.
We pass because the opportunity rating is none. Forward earnings sit at 85 times while return on equity runs at minus 42 percent and the moat stays unknown. Analyst targets cluster near 37 dollars but that optimism collides with an 18 percent negative margin of safety and a business still burning cash at scale.
The ethical screen clears yet the financial picture flags classic early stage biotech hazards: binary trial outcomes, dilution risk and the chance peak losses arrive before any durable product. Numbers this weak usually warn of further downside rather than hidden upside. Analysis, not advice.
| Forward P/E | 23.0xa premium valuation |
| EPS, trailing | -2.02 |
| EPS, forward | 1.17 |
| Revenue growth | -90.6%revenue is shrinking |
| Profit margin | 0.0%currently unprofitable |
| Return on equity | -72.3%not currently earning a positive return on equity |
| FCF yield | -3.47% |
| Debt to equity | 0.20minimal debt: a conservative balance sheet |
| Current ratio | 6.32comfortably covers its short-term bills |
| Beta | 1.19moves a little more than the market |
| Short interest, float | 0.10% |
| 52-week range | 15.79 - 31.34 |
| Market cap | $2.0B |
| Employees | 243 |
The risks · The things to watch: it's a small-cap, so the share price can swing harder than the market; as a biotechnology name, trial and regulatory outcomes can move it sharply either way.
Plain-English interpretation of our own screen data. Analysis, not advice.
Where & How to TradeZYME trades on Nasdaq. As a listed security it is accessible through almost any international broker offering its home market. New to this, or investing from abroad? Our guide to accessing global markets covers brokers, currencies and the practical steps.
Every Entry, As Written
The framework has shifted from markdown to markup since the last review. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Price has moved up 5.3% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows excellent risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is holding around 15% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 75%. Our forward projection puts the odds of a 10% gain over the next month near 40%. The street (13 analysts) rates it none, with a mean price target of $40.
The framework has shifted from distribution to markdown since the last review. Price is trending lower. Sellers are in control and the prior trend has reversed. Price has moved up 9.0% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows excellent risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is holding around 15% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 75%. Our forward projection puts the odds of a 10% gain over the next month near 40%. The street (13 analysts) rates it none, with a mean price target of $40.
The framework reads distribution. Smart money appears to be selling into strength. Institutional holders may be rotating out. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows excellent risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is holding around 15% above its long-term trend line with momentum reading neutral. Over the past year the shares are up 75%. Our forward projection puts the odds of a 10% gain over the next month near 40%. The street (13 analysts) rates it none, with a mean price target of $40.
The framework reads distribution. Smart money appears to be selling into strength. Institutional holders may be rotating out. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen (70). The risk-adjusted return profile shows excellent risk-adjusted returns.
The framework reads distribution. Smart money appears to be selling into strength. Institutional holders may be rotating out. Ethical screening: PASS with passing ethical screen (70). The risk-adjusted return profile shows excellent risk-adjusted returns.
Each entry above was written on its date, before the outcome. A journal you can prune is not a journal.
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Headlines from third-party outlets, linked for reference: not our reporting, not advice.
Screened names in the same industry · explore each on its own page.
| Period | Price then | Price return | Divs per share | $1,000 became | Total return |
|---|---|---|---|---|---|
| 1 month | $24.03 | -4.9% | · | $951 | -4.9% |
| 2 months | $26.32 | -13.2% | · | $868 | -13.2% |
| 3 months | $23.23 | -1.6% | · | $984 | -1.6% |
| 6 months | $24.94 | -8.4% | · | $916 | -8.4% |
| 1 year | $13.07 | +74.8% | · | $1,748 | +74.8% |
| 2 years | $8.97 | +154.7% | · | $2,547 | +154.7% |
| 3 years | $8.52 | +168.2% | · | $2,682 | +168.2% |
| 5 years | $37.73 | -39.4% | · | $606 | -39.4% |
Historical returns from market close data. Past performance does not guarantee future results.
This entry now belongs to the ledger. Whatever ZYME does next, these words stay.
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Join the deskScreening is research, not a fatwa and not financial advice. Figures are drawn from public accounts at the screen date shown. Always manage your risk.