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Vol. II · No. 256Sunday, 13 September 2026
TTitan Protect
The Screen · Healthcare · Biotechnology

Lexicon Pharmaceuticals, Inc.

LXRX · Nasdaq · USD · Market cap $974M · 81 employees

Lexicon Pharmaceuticals, Inc., a biopharmaceutical company, focuses on the discovery, development, and commercialization of pharmaceutical products for the treatment of human disease.

FAIL · Does not pass the screen
2.19 USD

At the last full screen
2026-09-01

Screened 2026-09-01 · the tape above runs as of 10:31 UTC · two dates, stated on purpose · verdict and workings shown in full · never trimmed

The Label · The Season, Not the Day

This name holds its markdown label.

Lexicon Pharmaceuticals, Inc. holds its Markdown at $2.19. Consolidating, no directional conviction, held for 67 days.

As held on the ledger · 2026-09-01
PhaseMarkdown · caution
Quantitative stateConsolidating, no directional conviction, held for 67 days
Price at the screen$2.19
ValuationN/A trailing · -11.49 forward price to earnings
Values screenFAIL · score 70.0
Beta1.04
The Workings

Five Screens, Shown in Full

Does not pass. Debt ratio

TestFigureLimitWhat it meansStatus
Business activity Permissible Core business clean Its core business isn't built on prohibited lines: no gambling, alcohol, tobacco, weapons, or interest-based lending. Pass
Debt load 33.96% Below 33% Interest-bearing debt is 34.0% of its assets, above the one-third ceiling the screen allows. Fail
Interest-bearing cash 33.46% Below 33% Interest-bearing cash and securities are 33.5% of assets, above the one-third limit. Fail
Receivables 19.84% Below 49% Money owed to the company is 19.8% of assets, under the 49% limit. Pass
Revenue purity 13.87% Below 5% 13.9% of revenue comes from non-compliant sources, over the 5% line. Fail

Five checks adapted from AAOIFI screening standards: business activity plus four balance-sheet ratios. All five must pass for ethical clearance. Every figure is arithmetic on public accounts, not judgement.

What the Numbers Say It Is Worth

The Fair Value Range

2.00Conservative3.10Base case4.38Growth case 2.19Price

Fair value range in USD, drawn from the 2026-09-01 screen. The gold marker is the market price at the same screen. A 41.6% margin of safety to the base estimate.

The Street's Range
2.00Street low 3.10Street average 6.00Street high 2.19Price

Third-party analyst targets: 5 covering, consensus Buy. The average target sits +42% from the screen price.

Reading the gap · Both our model and the analysts see meaningful upside from here.

Price History & Projections
$6.4$3.3$0.3TODAY5y agoPROJECTIONStreet high$6.00 +218%Street avg$3.10 +64%Our fair value$3.10 +64%Conservative$2.00 +6%

Where it has been, where the models see it going. History from market close data; projection points are our fair-value estimates and third-party analyst targets, dated to the 2026-09-01 screen.

Fair value and rating are our own model estimates; the Street's range reflects third-party analyst estimates. Analysis, not advice.

The Business, in Plain Words

Biotech Revenue Rocket Still Burns Cash

Picture a small lab finally shipping product after years of trials. Lexicon shows revenue exploding more than fifteen times over, yet every pound of sales still leaks away at a 37 percent loss rate and negative return on equity. With no economic moat identified and an opportunity rating of none, the business simply fails to clear our bar despite clearing the ethical screen.

The forward multiple sits at negative 11.6 times while five analysts see a median target only modestly above the current 2.39 price. Margin of safety looks attractive on paper at fair value 3.10, but negative earnings and unknown durability of that sudden top-line jump make the discount unreliable.

Risk sits with execution on sotagliflozin and the usual biotech cash burn that can erase any apparent value quickly. Analysis, not advice.

The fundamentals · plain-English read
Forward P/E-11.5x
EPS, trailing-0.16
EPS, forward-0.19
Revenue growth-97.6%revenue is shrinking
Profit margin-147.4%currently unprofitable
Return on equity-40.2%not currently earning a positive return on equity
FCF yield-4.59%
Debt to equity0.34minimal debt: a conservative balance sheet
Current ratio13.37comfortably covers its short-term bills
Beta1.04moves a little more than the market
Short interest, float0.14%
52-week range1.03 - 2.68
Market cap$974M
Employees81

The risks · The things to watch: it's a small-cap, so the share price can swing harder than the market; as a biotechnology name, trial and regulatory outcomes can move it sharply either way.

Plain-English interpretation of our own screen data. Analysis, not advice.

Where & How to Trade

LXRX trades on Nasdaq. As a listed security it is accessible through almost any international broker offering its home market. New to this, or investing from abroad? Our guide to accessing global markets covers brokers, currencies and the practical steps.

The Dated Journal · Newest First, Never Edited

Every Entry, As Written

2026-09-04 Markdown · changed $2.19 -8.4% Entry 5

The framework has shifted from accumulation to markdown since the last review. Price is trending lower. Sellers are in control and the prior trend has reversed. Price has moved down 8.4% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows good risk-adjusted returns. Our composite framework grades it B. Technically it is holding around 51% above its long-term trend line with momentum reading bullish. Over the past year the shares are up 169%. Our forward projection puts the odds of a 10% gain over the next month near 34%. The street (5 analysts) rates it none, with a mean price target of $4.

2026-08-05 Accumulation · changed $2.39 +24.5% Entry 4

The framework has shifted from markup to accumulation since the last review. Smart money appears to be quietly building positions. This typically precedes a markup phase. Price has moved up 24.5% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows good risk-adjusted returns. Our composite framework grades it B. Technically it is holding around 51% above its long-term trend line with momentum reading bullish. Over the past year the shares are up 169%. Our forward projection puts the odds of a 10% gain over the next month near 34%. The street (5 analysts) rates it none, with a mean price target of $4.

2026-07-18 Markup $1.92 +0.0% Entry 3

The framework reads markup. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows good risk-adjusted returns. Our composite framework grades it B. Technically it is holding around 51% above its long-term trend line with momentum reading bullish. Over the past year the shares are up 169%. Our forward projection puts the odds of a 10% gain over the next month near 34%. The street (5 analysts) rates it none, with a mean price target of $4.

2026-07-03 Markup $1.92 +0.0% Entry 2

The framework reads markup. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen (70). The risk-adjusted return profile shows good risk-adjusted returns.

2026-07-02 Markup $1.92 Entry 1

The framework reads markup. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Ethical screening: PASS with passing ethical screen (70). The risk-adjusted return profile shows good risk-adjusted returns.

Each entry above was written on its date, before the outcome. A journal you can prune is not a journal.

Related Securities · Others in LXRX's Space

Screened names in the same industry · explore each on its own page.

What Holding Actually Paid · Price Plus Dividends
If $1,000 had been placed · historical, not a promise
PeriodPrice thenPrice returnDivs per share$1,000 becameTotal return
1 month $2.31 -18.4% · $816 -18.4%
2 months $1.72 +9.6% · $1,096 +9.6%
3 months $1.72 +9.6% · $1,096 +9.6%
6 months $1.32 +42.8% · $1,428 +42.8%
1 year $0.70 +169.3% · $2,693 +169.3%
2 years $1.90 -0.8% · $992 -0.8%
3 years $2.83 -33.4% · $666 -33.4%
5 years $4.87 -61.3% · $387 -61.3%

Historical returns from market close data. Past performance does not guarantee future results.

The Ledger's Promise

This entry now belongs to the ledger. Whatever LXRX does next, these words stay.

Lexicon Pharmaceuticals, Inc. · LXRX · Markdown · $2.19
Recorded 2026-09-01 · before the outcome · scored mechanically

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Screening is research, not a fatwa and not financial advice. Figures are drawn from public accounts at the screen date shown. Always manage your risk.

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