The framework has shifted from markdown to markup since the last review. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Price has moved up 18.8% since our last review. Ethical screening: FAIL. This security does not pass our values-based screening criteria. The risk-adjusted return profile shows good risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is momentum reading bearish. Over the past year the shares are up 1%. Our forward projection puts the odds of a 10% gain over the next month near 33%. The street (21 analysts) rates it strong buy, with a mean price target of $197.
Insmed Inc
INSM · NASDAQ · USD · Market cap $27.7B · 1,664 employees
Insmed Incorporated develops and commercializes therapies for patients with serious and rare diseases in the United States, Europe, Japan, and internationally.
FAIL · Does not pass the screenAt the last full screen
2026-09-02
Screened 2026-09-02 · the tape above runs as of 17:00 UTC · two dates, stated on purpose · verdict and workings shown in full · never trimmed
This name holds its markdown label.
Insmed Inc holds its Markdown at $126.63. The statistical read favours the sellers, held for 19 days.
| Phase | Markdown · caution |
| Quantitative state | The statistical read favours the sellers, held for 19 days |
| Price at the screen | $126.63 |
| Valuation | N/A trailing · 157.85 forward price to earnings |
| Values screen | FAIL · score 70.0 |
| Beta | 0.79 |
Five Screens, Shown in Full
Does not pass. Interest-bearing securities
| Test | Figure | Limit | What it means | Status |
|---|---|---|---|---|
| Business activity | Permissible | Core business clean | Its core business isn't built on prohibited lines: no gambling, alcohol, tobacco, weapons, or interest-based lending. | Pass |
| Debt load | 25.91% | Below 33% | Interest-bearing debt is just 25.9% of its assets, well under the one-third ceiling: it does not run on borrowed money. | Pass |
| Interest-bearing cash | 40.61% | Below 33% | Interest-bearing cash and securities are 40.6% of assets, above the one-third limit. | Fail |
| Receivables | 28.76% | Below 49% | Money owed to the company is 28.8% of assets, under the 49% limit. | Pass |
| Revenue purity | 0.00% | Below 5% | Only 0.0% of revenue comes from non-compliant sources, under the 5% line. | Pass |
Five checks adapted from AAOIFI screening standards: business activity plus four balance-sheet ratios. All five must pass for ethical clearance. Every figure is arithmetic on public accounts, not judgement.
What the Numbers Say It Is WorthThe Fair Value Range
Fair value range in USD, drawn from the 2026-09-02 screen. The gold marker is the market price at the same screen. The price runs 15.0% above the base estimate.
Third-party analyst targets: 22 covering, consensus Strong Buy. The average target sits +56% from the screen price.
Reading the gap · Our more conservative model reads it as fully-to-richly valued here, while the Street is more bullish: a quality-at-a-fair-price name rather than a deep-value one.
Price History & ProjectionsWhere it has been, where the models see it going. History from market close data; projection points are our fair-value estimates and third-party analyst targets, dated to the 2026-09-02 screen.
Fair value and rating are our own model estimates; the Street's range reflects third-party analyst estimates. Analysis, not advice.
The Business, in Plain WordsRare disease biotech priced for perfection
A patient in Japan finally clearing a stubborn lung infection marks real progress for families who had few options before. Insmed is delivering that progress, with revenue up 230 percent as its lead therapy gains ground across the US, Europe and Japan.
Yet the shares sit 6 percent above our fair value at an 814 times forward multiple while margins sit at minus 144 percent and return on equity at minus 294 percent. Narrow moat and strong buy analyst targets do not change the fact that current pricing leaves almost no margin of safety.
Execution risk in rare disease trials, regulatory delays abroad and the need to turn rapid top line growth into actual profits remain the central concerns. Analysis, not advice.
| Forward P/E | 157.8xcheap for a company growing this fast |
| EPS, trailing | -4.12 |
| EPS, forward | 0.80 |
| Revenue growth | +296.1%growing very fast |
| Profit margin | -76.9%currently unprofitable |
| Return on equity | -87.2%not currently earning a positive return on equity |
| FCF yield | -2.07% |
| Debt to equity | 0.98moderate, manageable leverage |
| Current ratio | 3.72comfortably covers its short-term bills |
| Beta | 0.79steadier than the market |
| Short interest, float | 0.06% |
| 52-week range | 90.39 - 212.75 |
| Moat | NARROW |
| Market cap | $27.7B |
| Employees | 1,664 |
The risks · The things to watch: as a biotechnology name, trial and regulatory outcomes can move it sharply either way.
Plain-English interpretation of our own screen data. Analysis, not advice.
Where & How to TradeINSM trades on NASDAQ. As a listed security it is accessible through almost any international broker offering its home market. New to this, or investing from abroad? Our guide to accessing global markets covers brokers, currencies and the practical steps.
Every Entry, As Written
The framework has shifted from distribution to markdown since the last review. Price is trending lower. Sellers are in control and the prior trend has reversed. Price has moved up 6.4% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows good risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is momentum reading bearish. Over the past year the shares are up 1%. Our forward projection puts the odds of a 10% gain over the next month near 33%. The street (21 analysts) rates it strong buy, with a mean price target of $197.
The framework reads distribution. Smart money appears to be selling into strength. Institutional holders may be rotating out. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows good risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is momentum reading bearish. Over the past year the shares are up 1%. Our forward projection puts the odds of a 10% gain over the next month near 33%. The street (21 analysts) rates it strong buy, with a mean price target of $197.
The framework reads distribution. Smart money appears to be selling into strength. Institutional holders may be rotating out. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen (70). The risk-adjusted return profile shows good risk-adjusted returns.
The framework reads distribution. Smart money appears to be selling into strength. Institutional holders may be rotating out. Ethical screening: PASS with passing ethical screen (70). The risk-adjusted return profile shows good risk-adjusted returns.
Each entry above was written on its date, before the outcome. A journal you can prune is not a journal.
- Arbutus, Sanofi escalate mRNA patent fights; InnoCare’s TYK2 contender advances BioPharma Dive · 17 Jul 2026
- Insmed's TPIP Shows Durable PAH Benefits in 12-Month Study MarketBeat · 16 Jul 2026
- Here’s Why TimesSquare Mid Cap Growth Strategy Added Insmed (INSM) Insider Monkey · 1 Jul 2026
- Mizuho Maintains an Outperform Rating on Insmed Incorporated (INSM) Insider Monkey · 28 Jun 2026
- Nebius and CoreWeave fall after Nasdaq 100 listing Blockspace · 23 Jun 2026
Headlines from third-party outlets, linked for reference: not our reporting, not advice.
Screened names in the same industry · explore each on its own page.
| Period | Price then | Price return | Divs per share | $1,000 became | Total return |
|---|---|---|---|---|---|
| 1 month | $103.89 | -12.0% | · | $880 | -12.0% |
| 2 months | $154.81 | -41.0% | · | $590 | -41.0% |
| 3 months | $139.52 | -34.5% | · | $655 | -34.5% |
| 6 months | $195.24 | -53.2% | · | $468 | -53.2% |
| 1 year | $90.93 | +0.5% | · | $1,005 | +0.5% |
| 2 years | $59.90 | +52.6% | · | $1,526 | +52.6% |
| 3 years | $19.80 | +361.5% | · | $4,615 | +361.5% |
| 5 years | $30.06 | +204.0% | · | $3,040 | +204.0% |
Historical returns from market close data. Past performance does not guarantee future results.
This entry now belongs to the ledger. Whatever INSM does next, these words stay.
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Join the deskScreening is research, not a fatwa and not financial advice. Figures are drawn from public accounts at the screen date shown. Always manage your risk.