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The Screen · Healthcare · Biotechnology

Vertex Pharmaceuticals

VRTX · a US exchange · USD · Market cap $134.1B · 6,400 employees

Vertex Pharmaceuticals Incorporated operates as a biotechnology company in the United States, Europe, and internationally.

PASS · Titan Ethical · score 71.4
528.90 USD

At the last full screen
2026-09-08

Screened 2026-09-08 · the tape above runs as of 21:00 UTC · two dates, stated on purpose · verdict and workings shown in full · never trimmed

The Label · The Season, Not the Day

This name holds its distribution label.

Vertex Pharmaceuticals holds its Distribution at $528.90. The statistical read favours the buyers, held for 34 days.

As held on the ledger · 2026-09-08
PhaseDistribution · caution
Quantitative stateThe statistical read favours the buyers, held for 34 days
Price at the screen$528.90
Valuation30.84 trailing · 26.15 forward price to earnings
Values screenPASS · score 71.4
Beta0.32
The Workings

Five Screens, Shown in Full

Full pass across all five screens. This security clears the Titan Ethical Standard: its business and its balance sheet both stay inside the lines.

TestFigureLimitWhat it meansStatus
Business activity Permissible Core business clean Its core business isn't built on prohibited lines: no gambling, alcohol, tobacco, weapons, or interest-based lending. Pass
Debt load 7.92% Below 33% Interest-bearing debt is just 7.9% of its assets, well under the one-third ceiling: it does not run on borrowed money. Pass
Interest-bearing cash 22.28% Below 33% Cash held in interest-bearing accounts and securities is 22.3% of assets, under the one-third limit. Pass
Receivables 27.83% Below 49% Money owed to the company is 27.8% of assets, under the 49% limit. Pass
Revenue purity 4.09% Below 5% Only 4.1% of revenue comes from non-compliant sources, under the 5% line. Pass

Five checks adapted from AAOIFI screening standards: business activity plus four balance-sheet ratios. All five must pass for ethical clearance. Every figure is arithmetic on public accounts, not judgement.

What the Numbers Say It Is Worth

The Fair Value Range

Our framework reads OVERVALUED: it trades above our $496.75 fair value estimate, strong competitive moat, 12.50% revenue growth.

315.00Conservative496.75Base case571.26Growth case 528.90Price

Fair value range in USD, drawn from the 2026-09-08 screen. The gold marker is the market price at the same screen. The price runs 6.1% above the base estimate.

The Street's Range
350.00Street low 577.50Street average 672.00Street high 528.90Price

Third-party analyst targets: 26 covering, consensus Buy. The average target sits +9% from the screen price.

Reading the gap · Our more conservative model reads it as fully-to-richly valued here, while the Street is more bullish: a quality-at-a-fair-price name rather than a deep-value one.

Price History & Projections
$710$433$155TODAY5y agoPROJECTIONStreet high$672.00 +54%Street avg$577.50 +33%Our fair value$496.75 +14%Conservative$315.00 -28%

Where it has been, where the models see it going. History from market close data; projection points are our fair-value estimates and third-party analyst targets, dated to the 2026-09-08 screen.

Fair value and rating are our own model estimates; the Street's range reflects third-party analyst estimates. Analysis, not advice.

The Business, in Plain Words

Vertex's Strong Moat Amidst the Healthcare Race

Imagine a pharmaceutical track where Vertex Pharmaceuticals is sprinting ahead in the specialty markets, particularly in cystic fibrosis and sickle cell disease. With a strong moat and a focus on transformative medicines, Vertex stands out with a 35% profit margin and a 24% return on equity. Its revenue growth is a steady 12%, demonstrating a consistent expansion in its market footprint.

Despite its robust performance, our fair value assessment places Vertex at $525.29, suggesting the stock is overvalued with a -3% margin of safety at its current price of $540.26. The consensus of 25 analysts is bullish, with a median target of $570, yet our opportunity rating labels it as overvalued. Given its strong financials and ethical pass, Vertex could be a strong contender for investors seeking ethical growth in healthcare.

Risks are inherent in any pharmaceutical investment, with Vertex being no exception. The forward P/E of 24.7x indicates a premium valuation, and while the business has a strong ethical foundation, the potential for regulatory hurdles and the high cost of drug development should be considered. The market is also pricing in expectations of continued growth, which, if not met, could lead to a reassessment of its valuation. Analysis, not advice.

The fundamentals · plain-English read
Forward P/E26.1xexpensive even after accounting for its growth
Trailing P/E30.8xa premium valuation
EPS, trailing17.15
EPS, forward20.23
Revenue growth+12.5%steady growth
Profit margin35.0%highly profitable on every dollar of sales
Return on equity23.5%an exceptional return on shareholder capital
FCF yield1.96%
Debt to equity0.10minimal debt: a conservative balance sheet
Current ratio3.19comfortably covers its short-term bills
Beta0.32barely tracks the market's swings
Short interest, float0.02%
52-week range374.17 - 560.25
MoatSTRONG
Market cap$134.1B
Employees6,400

The risks · The things to watch: as a biotechnology name, trial and regulatory outcomes can move it sharply either way.

Plain-English interpretation of our own screen data. Analysis, not advice.

Where & How to Trade

VRTX trades on a US exchange. As a listed security it is accessible through almost any international broker offering its home market. New to this, or investing from abroad? Our guide to accessing global markets covers brokers, currencies and the practical steps.

The Dated Journal · Newest First, Never Edited

Every Entry, As Written

2026-09-03 Markup $540.26 +13.2% Entry 11

The framework reads markup. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Price has moved up 13.2% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows modest positive risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is holding around 0% above its long-term trend line with momentum reading neutral. Over the past year the shares are down 4%. Our forward projection puts the odds of a 10% gain over the next month near 18%. The street (29 analysts) rates it buy, with a mean price target of $548.

2026-08-03 Markup $477.36 +0.0% Entry 10

The framework reads markup. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows modest positive risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is holding around 0% above its long-term trend line with momentum reading neutral. Over the past year the shares are down 4%. Our forward projection puts the odds of a 10% gain over the next month near 18%. The street (29 analysts) rates it buy, with a mean price target of $548. It reported earnings in this window, a natural checkpoint for the thesis.

2026-08-02 Markup $477.36 +0.0% Entry 9

The framework reads markup. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows modest positive risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is holding around 0% above its long-term trend line with momentum reading neutral. Over the past year the shares are down 4%. Our forward projection puts the odds of a 10% gain over the next month near 18%. The street (29 analysts) rates it buy, with a mean price target of $548. It reported earnings in this window, a natural checkpoint for the thesis.

2026-08-01 Markup $477.36 +0.0% Entry 8

The framework reads markup. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows modest positive risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is holding around 0% above its long-term trend line with momentum reading neutral. Over the past year the shares are down 4%. Our forward projection puts the odds of a 10% gain over the next month near 18%. The street (29 analysts) rates it buy, with a mean price target of $548. It reported earnings in this window, a natural checkpoint for the thesis.

2026-07-31 Markup $477.36 +0.0% Entry 7

The framework reads markup. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows modest positive risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is holding around 0% above its long-term trend line with momentum reading neutral. Over the past year the shares are down 4%. Our forward projection puts the odds of a 10% gain over the next month near 18%. The street (29 analysts) rates it buy, with a mean price target of $548. It reported earnings in this window, a natural checkpoint for the thesis.

2026-07-30 Markup · changed $477.36 +0.0% Entry 6

The framework has shifted from accumulation to markup since the last review. Price is trending higher with momentum. The crowd has caught on and buyers are in control. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows modest positive risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is holding around 0% above its long-term trend line with momentum reading neutral. Over the past year the shares are down 4%. Our forward projection puts the odds of a 10% gain over the next month near 18%. The street (29 analysts) rates it buy, with a mean price target of $548. It reported earnings in this window, a natural checkpoint for the thesis.

2026-07-28 Accumulation $477.36 +0.0% Entry 5

The framework reads accumulation. Smart money appears to be quietly building positions. This typically precedes a markup phase. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows modest positive risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is holding around 0% above its long-term trend line with momentum reading neutral. Over the past year the shares are down 4%. Our forward projection puts the odds of a 10% gain over the next month near 18%. The street (29 analysts) rates it buy, with a mean price target of $548. It reported earnings in this window, a natural checkpoint for the thesis.

2026-07-27 Accumulation $477.36 +6.8% Entry 4

The framework reads accumulation. Smart money appears to be quietly building positions. This typically precedes a markup phase. Price has moved up 6.8% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows modest positive risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is holding around 0% above its long-term trend line with momentum reading neutral. Over the past year the shares are down 4%. Our forward projection puts the odds of a 10% gain over the next month near 18%. The street (29 analysts) rates it buy, with a mean price target of $548. It reported earnings in this window, a natural checkpoint for the thesis.

2026-07-18 Accumulation $446.83 +0.0% Entry 3

The framework reads accumulation. Smart money appears to be quietly building positions. This typically precedes a markup phase. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen. The risk-adjusted return profile shows modest positive risk-adjusted returns. Our composite framework grades it C, carrying a low risk profile. Technically it is holding around 0% above its long-term trend line with momentum reading neutral. Over the past year the shares are down 4%. Our forward projection puts the odds of a 10% gain over the next month near 18%. The street (29 analysts) rates it buy, with a mean price target of $548.

2026-07-03 Accumulation $446.83 +0.0% Entry 2

The framework reads accumulation. Smart money appears to be quietly building positions. This typically precedes a markup phase. Price has moved down 0.0% since our last review. Ethical screening: PASS with passing ethical screen (71). The risk-adjusted return profile shows modest positive risk-adjusted returns.

Each entry above was written on its date, before the outcome. A journal you can prune is not a journal.

Latest News · What the Market Is Reading on VRTX

Headlines from third-party outlets, linked for reference: not our reporting, not advice.

Related Securities · Others in VRTX's Space

Screened names in the same industry · explore each on its own page.

The Insider Ledger · Form 4 Filings, As Filed
Most recent filings · VRTX
DateInsiderTitleTypeSharesValue
2026-05-15 BUNNAGE MARK E. Officer 33 $14,964
2026-05-15 BOZIC CARMEN Officer 1,354 $613,971
2026-05-12 BOZIC CARMEN Officer 6,988 $3,144,600
2026-05-04 BHATIA SANGEETA N Director 318 $134,746
2026-05-01 THORNBERRY NANCY A. Director 472 ·
2026-05-01 BHATIA SANGEETA N Director 943 ·
2026-05-01 MCKENZIE DIANA L Director 943 ·
2026-05-01 SCHNEIDER JENNIFER J Director 472 ·
2026-05-01 GARBER ALAN M Director 472 ·
2026-05-01 LIU JOY Officer 1,104 $469,222

Public filings, recorded as found. The full tape lives at Insider Intelligence.

The Political Ledger · Congressional Disclosures
Disclosures naming VRTX
DatePoliticianPartyTypeAmount
2026-08-26 David Taylor Republican sell 1K–15K
2026-08-26 David Taylor Republican sell 1K–15K
2026-08-26 David Taylor Republican sell 1K–15K
2026-04-13 Ro Khanna Democrat Purchase 1K–15K
2026-03-27 Alan Armstrong Republican buy 1K–15K
What Holding Actually Paid · Price Plus Dividends
If $1,000 had been placed · historical, not a promise
PeriodPrice thenPrice returnDivs per share$1,000 becameTotal return
1 month $435.17 +0.1% · $1,001 +0.1%
2 months $436.27 -0.1% · $999 -0.1%
3 months $478.13 -8.9% · $911 -8.9%
6 months $445.93 -2.3% · $977 -2.3%
1 year $451.52 -3.5% · $965 -3.5%
2 years $483.28 -9.8% · $902 -9.8%
3 years $334.11 +30.4% · $1,304 +30.4%
5 years $193.02 +125.7% · $2,257 +125.7%

Historical returns from market close data. Past performance does not guarantee future results.

The Ledger's Promise

This entry now belongs to the ledger. Whatever VRTX does next, these words stay.

Vertex Pharmaceuticals · VRTX · Distribution · $528.90
Recorded 2026-09-08 · before the outcome · scored mechanically

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